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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Hur, Beong Ik (Department of Neurosurgery, School of Medicine, Pusan National University) Lee, Jae Min (Department of Neurosurgery, School of Medicine, Pusan National University) Cho, Won Ho (Department of Neurosurgery, School of Medicine, Pusan National University) Kang, Dong Wan (Department of Neurosurgery, School of Medicine, Pusan National University) Kim, Choong Rak (Department of Statistics, Pusan National University) Choi, Byung Kwan (Department of Neurosurgery, School of Medicine, Pusan National University)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제53권 제2호
발행연도
2013.1
수록면
102 - 107 (6page)

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Objective : The Leksell Gamma Knife$^{(R)}$ (LGK) is based on a single-fraction high dose treatment strategy. Therefore, independent verification of the Leksell GammaPlan$^{(R)}$ (LGP) is important for ensuring patient safety and minimizing the risk of treatment errors. Although several verification techniques have been previously developed and reported, no method has ever been tested statistically on multiple LGK target treatments. The purpose of this study was to perform and to evaluate the accuracy of a verification method (modified variable ellipsoid modeling technique, MVEMT) for multiple target treatments. Methods : A total of 500 locations in 10 consecutive patients with multiple brain tumor targets were included in this study. We compared the data from an LGP planning system and MVEMT in terms of dose at random points, maximal dose points, and target volumes. All data was analyzed by t-test and the Bland-Altman plot, which are statistical methods used to compare two different measurement techniques. Results : No statistical difference in dose at the 500 random points was observed between LGP and MVEMT. Differences in maximal dose ranged from -2.4% to 6.1%. An average distance of 1.6 mm between the maximal dose points was observed when comparing the two methods. Conclusion : Statistical analyses demonstrated that MVEMT was in excellent agreement with LGP when planning for radiosurgery involving multiple target treatments. MVEMT is a useful, independent tool for planning multiple target treatment that provides statistically identical data to that produced by LGP. Findings from the present study indicate that MVEMT can be used as a reference dose verification system for multiple tumors.
#Brain tumor #Gamma Knife #Radiation dose #Radiosurgery

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참고문헌 (14)

참고문헌 신청
Arai Y / 2010 / Does the Gamma Knife dose rate affect outcomes in radiosurgery for trigeminal neuralgia? / J Neurosurg (113 Suppl):168~171 google schola Aubuchon AC / 2011 / Repeat gamma knife radiosurgery for trigeminal neuralgia / Int J Radiat Oncol Biol Phys 81:1059~1065 google schola Bland JM / 1986 / Statistical methods for assessing agreement between two methods of clinical measurement / Lancet 1:307~310 google schola Brisman R / 2000 / Gamma knife radiosurgery for primary management for trigeminal neuralgia / J Neurosurg 93(Suppl 3):159~161 google schola Brisman R / 2004 / Gamma knife surgery with a dose of 75 to 76.8 Gray for trigeminal neuralgia / J Neurosurg 100:848~854 google schola

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