지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 328 - 333 (6page)
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Objective : The aim of this study is to determine the association between the cerebrospinal fluid (CSF) biomarkers and inflammation, and the predictive value of these CSF biomarkers for subsequent shunt associated infection. Methods : We obtained CSF samples from the patients with hydrocephalus during ventriculoperitoneal (VP) shunt operations. Twenty-two patients were enrolled for this study and divided into 3 groups: subarachnoid hemorrhage (SAH)-induced hydrocephalus, idiopathic normal pressure hydrocephalus (INPH) and hydrocephalus with a subsequent shunt infection. We analyzed the transforming growth factor-${\beta}1$, tumor necrosis factor-${\alpha}$, vascular endothelial growth factor (VEGF) and total tau in the CSF by performing enzyme-linked immunosorbent assay. The subsequent development of shunt infection was confirmed by the clinical presentations, the CSF parameters and CSF culture from the shunt devices. Results : The mean VEGF concentration (${\pm}$standard deviation) in the CSF of the SAH-induced hydrocephalus, INPH and shunt infection groups was $236{\pm}138$, $237{\pm}80$ and $627{\pm}391$ pg/mL, respectively. There was a significant difference among the three groups (p=0.01). Between the SAH-induced hydrocephalus and infection groups and between the INPH and infection groups, there was a significant difference of the VEGF levels (p<0.01). However, the other marker levels did not differ among them. Conclusion : The present study showed that only the CSF VEGF levels are associated with the subsequent development of shunt infection. Our results suggest that increased CSF VEGF could provide a good condition for bacteria that are introduced at the time of surgery to grow in the brain, rather than reflecting a sequel of bacterial infection before VP shunt.
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참고문헌 (34)
참고문헌 신청
Bayston R / 1997 / Duration of protective activity of cerebrospinal fluid shunt catheters impregnated with antimicrobial agents to prevent bacterial catheter-related infection / J Neurosurg 87:247~251
Cheng SY / 1997 / Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189 / Proc Natl Acad Sci U S A 94:12081~12087
Del Bigio MR / 1989 / Hydrocephalus-induced changes in the composition of cerebrospinal fluid / Neurosurgery 25:416~423
Esser S / 1998 / Vascular endothelial growth factor induces endothelial fenestrations in vitro / J Cell Biol 140:947~959
Flood C / 2001 / Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage : titers derived from exogenous and endogenous sources / J Cereb Blood Flow Metab 21:157~162
Cheng SY / 1997 / Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189 / Proc Natl Acad Sci U S A 94:12081~12087
Del Bigio MR / 1989 / Hydrocephalus-induced changes in the composition of cerebrospinal fluid / Neurosurgery 25:416~423
Esser S / 1998 / Vascular endothelial growth factor induces endothelial fenestrations in vitro / J Cell Biol 140:947~959
Flood C / 2001 / Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage : titers derived from exogenous and endogenous sources / J Cereb Blood Flow Metab 21:157~162
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