Significance of C-Reactive Protein and Transcranial Doppler in Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage

Hwang, Sung-Hwan; Park, Yong-Sook; Kwon, Jeong-Taik; Nam, Taek-Kyun; Hwang, Sung-Nam; Kang, Hyun

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자료유형: 학술저널

저자정보: Hwang, Sung-Hwan (Department of Neurosurgery, Chung-Ang University College of Medicine) Park, Yong-Sook (Department of Neurosurgery, Chung-Ang University College of Medicine) Kwon, Jeong-Taik (Department of Neurosurgery, Chung-Ang University College of Medicine) Nam, Taek-Kyun (Department of Neurosurgery, Chung-Ang University College of Medicine) Hwang, Sung-Nam (Department of Neurosurgery, Chung-Ang University College of Medicine) Kang, Hyun (Medical Device Clinical Trials Center, Chung-Ang University College of Medicine)

저널정보: 대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제54권 제4호

발행연도: 2013.1

수록면: 289 - 295 (7page)

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Objective : Cerebral vasospasm is a common and potentially devastating complication of aneurysmal subarachnoid hemorrhage (aSAH). Inflammatory processes seem to play a major role in the pathogenesis of vasospasm. C-reactive protein (CRP) constitutes a highly sensitive inflammatory marker. Elevation of serum CRP levels has been demonstrated in patients with aSAH. The purpose of the current study was to evaluate the possible relationship between CRP levels in the serum and transcranial Doppler (TCD) and the development of vasospasm in patients with aSAH. Methods : A total of 61 adult patients in whom aSAH was diagnosed were included in the study from November 2008 to May 2011. The patients' demographics, Hunt and Hess grade, Fisher grade, CT scans, digital subtraction angiography studies, and daily neurological examinations were recorded. Serial serum CRP measurements were obtained on days 1, 3, 5, 7, 9, 11 and 13 and TCD was measured on days 3, 5, 7, 9, 11 and 13. All patients underwent either surgical or endovascular treatment within 24 hours of their hemorrhagic attacks. Results : Serum CRP levels peaked on the 3rd postoperative day. There were significant differences between the vasospasm group and the non-vasospasm group on the 1st, 3rd and 5th day. There were significant differences between the vasospasm group and the non-vasospasm group on the 3rd day in the mean middle cerebral artery velocities on TCD. Conclusion : Patients with high levels of CRP on the 1st postoperative day and high velocity of mean TCD on the 3rd postoperative day may require closer observation to monitor for the development of vasospasm.

#Cerebral aneurysms #C-reactive protein #Subarachnoid hemorrhage #Vasospasm

참고문헌 (33)

참고문헌 신청

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