지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : The study examined the difference in the incidence of symptomatic cerebral vasospasm with magnesium supplementation in aneurysmal subarachnoid hemorrhage (SAH) in a Korean population. Methods : This retrospective analysis was performed in 157 patients diagnosed with aneurysmal SAH from January 2007 to December 2011 at a single center. Seventy patients (44.6%) received a combination treatment of nimodipine with magnesium and 87 patients (55.4%) received only nimodipine. A matched case-control study using propensity scores was conducted and 41 subjects were selected from each group. A dosage of 64 mmol/day of magnesium was administrated. Results : The infusion of magnesium did not reduce the incidence of symptomatic cerebral vasospasm (n=7, 17.1%, p=0.29) compared with simple nimodipine injection (n=11, 26.8%). The ratios of good clinical outcome (modified Rankin scale 0-2) at 6 months were similar, being 78% in the combination treatment group and 80.5% in the nimodipine only group (p=0.79). The proportions of delayed cerebral infarction was not significantly lower in patients with combination treatment (n=2, 4.9% vs. n=3, 7.3%; p=0.64). There was no difference in the serum magnesium concentrations between the patients with symptomatic vasospasm and without vasospasm who had magnesium supplementation. No major complications associated with intravenous magnesium infusion were observed. Conclusion : Magnesium supplementation (64 mmol/day) may not be beneficial for the reduction of the incidence of symptomatic cerebral vasospasm in patients with aneurysmal SAH.
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참고문헌 (24)
참고문헌 신청
Altura BT / 1984 / Interactions of Mg and K on cerebral vessels--aspects in view of stroke. Review of present status and new findings / Magnesium 3:195~211
Barbarawi M / 2009 / Therapeutic approaches to cerebral vasospasm complicating ruptured aneurysm / Neurol Int 1:13
Biondi A / 2004 / Intra-arterial nimodipine for the treatment of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage : preliminary results / AJNR Am J Neuroradiol 25:1067~1076
Boet R / 2000 / Magnesium sulfate in the management of patients with Fisher Grade 3 subarachnoid hemorrhage : a pilot study / Neurosurgery 47:602~606
Collignon FP / 2004 / Serum magnesium levels as related to symptomatic vasospasm and outcome following aneurysmal subarachnoid hemorrhage / Neurocrit Care 1:441~448
Barbarawi M / 2009 / Therapeutic approaches to cerebral vasospasm complicating ruptured aneurysm / Neurol Int 1:13
Biondi A / 2004 / Intra-arterial nimodipine for the treatment of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage : preliminary results / AJNR Am J Neuroradiol 25:1067~1076
Boet R / 2000 / Magnesium sulfate in the management of patients with Fisher Grade 3 subarachnoid hemorrhage : a pilot study / Neurosurgery 47:602~606
Collignon FP / 2004 / Serum magnesium levels as related to symptomatic vasospasm and outcome following aneurysmal subarachnoid hemorrhage / Neurocrit Care 1:441~448
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