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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : The aim of this study was to describe a single center's experience in the management of craniopharyngiomas in children over a 15-year period. Methods : The clinical records of pediatric patients treated for craniopharyngiomas between December 1995 and February 2011 were reviewed. Thirty-five pediatric patients diagnosed with craniopharyngioma were treated, and their medical records and imaging data were analyzed retrospectively. Results : The mean follow-up duration was 76 months (range, 10-195). Overall survival and local control rates at 10 years were $94.7{\pm}5.1%$ and $37.1{\pm}11.9%$, respectively. The female-to-male ratio was 16 : 19, and the mean age was 8.6 years (range, 1-17). Initially, gross total resection (GTR) was performed in 30 patients; subtotal resection (STR) followed by radiotherapy was performed in 5 patients. Of the 14 cases that showed recurrence after GTR, 5 patients were treated with GTR, 1 with radiation therapy (RT), 4 with gamma knife radiosurgery (GKRS), and 4 with subtotal resection followed by RT. No patients who underwent RT or GKRS had recurrences. Two cases with recurrence after STR followed by RT were treated with GTR. One patient died of hormonal insufficiency 64 months after the first surgery. The overall median time progression was 51.2 months (range, 3-182) : 49.7 months in the patients who underwent GTR and 60.2 months in the patients who underwent STR followed by RT. Conclusion : If safe resection is possible, GTR at the initial treatment should be attempted to reduce the tumor recurrence. However, if the tumor recurs after the first surgery, RT or GKRS with/without reoperation may be an effective salvage treatment for recurrent craniopharyngioma.
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참고문헌 (21)
참고문헌 신청
Aquilina K / 2010 / Malignant transformation of irradiated craniopharyngioma in children : report of 2 cases / J Neurosurg Pediatr 5:155~161
Chung WY / 2000 / Gamma knife radiosurgery for craniopharyngiomas / J Neurosurg 93(Suppl 3):47~56
Elliott RE / 2010 / Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children / J Neurosurg Pediatr 5:30~48
Fahlbusch R / 1999 / Surgical treatment of craniopharyngiomas : experience with 168 patients / J Neurosurg 90:237~250
Fisher PG / 1998 / Outcomes and failure patterns in childhood craniopharyngiomas / Childs Nerv Syst 14:558~563
Chung WY / 2000 / Gamma knife radiosurgery for craniopharyngiomas / J Neurosurg 93(Suppl 3):47~56
Elliott RE / 2010 / Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children / J Neurosurg Pediatr 5:30~48
Fahlbusch R / 1999 / Surgical treatment of craniopharyngiomas : experience with 168 patients / J Neurosurg 90:237~250
Fisher PG / 1998 / Outcomes and failure patterns in childhood craniopharyngiomas / Childs Nerv Syst 14:558~563
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