지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 431 - 435 (5page)
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초록· 키워드
오류제보하기
A fifty-year-old female non-smoker with no other specific medical history visited our institute. She complained of axial back pain with no other neurological deficit. Chest X-ray, chest computed tomography (CT) scan, CT-guided needle aspiration biopsy, whole-body positron emission tomography, spine CT and spine magnetic resonance image findings suggested NSCLC with epidermal growth factor receptor (EGFR) mutation, multiple brain metastases, and two isolated metastases to the T3 and L3 vertebral bodies. She underwent chemotherapy with gefitinib ($Iressa^{TM}$) for NSCLC and gamma knife surgery for multiple brain metastases. We performed a two-staged, total en bloc spondylectomy of the T3 and L3 vertebral bodies based on several good prognostic characteristics, such as the lack of metastases to the appendicular bone, good preoperative performance status, and being an excellent responder (Asian, never-smoker and adenocarcinoma histology) to EGFR inhibitors. Improved axial back pain after the surgery enabled her to walk with the aid of a thoracolumbosacral orthosis brace on the third postoperative day. Her Karnofsky performance status score (KPS) was 90 at the time of discharge and has been maintained to date 3 years after surgery. In selected NSCLC patients with good prognostic characteristics, we suggest that locally curative treatment such as total en bloc spondylectomy or radiosurgery should be emphasized to achieve longer term survival for the selected cases.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Aoude AA / 2012 / Surgical treatment of a patient with lung cancer metastasized to the spine with EGFR mutation : a case report / Int J Surg Case Rep 3:510~512
Brown T / 2010 / Gefitinib for the first-line treatment of locally advanced or metastatic non-small cell lung cancer / Health Technol Assess 14(Suppl 2):71~79
Herbst RS / 2002 / Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors : results of a phase I trial / J Clin Oncol 20:3815~3825
Hsieh PC / 2009 / Posterior-only approach for total en bloc spondylectomy for malignant primary spinal neoplasms : anatomic considerations and operative nuances / Neurosurgery 65(6 Suppl):173~181
Ibrahim A / 2008 / Does spinal surgery improve the quality of life for those with extradural (spinal) osseous metastases? An international multicenter prospective observational study of 223 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2007 / J Neurosurg Spine 8:271~278
Brown T / 2010 / Gefitinib for the first-line treatment of locally advanced or metastatic non-small cell lung cancer / Health Technol Assess 14(Suppl 2):71~79
Herbst RS / 2002 / Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors : results of a phase I trial / J Clin Oncol 20:3815~3825
Hsieh PC / 2009 / Posterior-only approach for total en bloc spondylectomy for malignant primary spinal neoplasms : anatomic considerations and operative nuances / Neurosurgery 65(6 Suppl):173~181
Ibrahim A / 2008 / Does spinal surgery improve the quality of life for those with extradural (spinal) osseous metastases? An international multicenter prospective observational study of 223 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2007 / J Neurosurg Spine 8:271~278
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