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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 107 - 111 (5page)
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Objective : We investigated the effectiveness of stereotactic gamma knife Radiosurgery (GKR) for radioresistant brain metastases with the impact upon histology. Methods : Between April 2004 and May 2011, a total of 23 patients underwent GKR for 67 metastatic brain tumors from 12 renal cell cancers, 5 sarcomas and 6 melanomas. The mean age was 56 years (range, 18 to 79 years). Most of the patients were classified as the Radiation Therapy Oncology Group recursive partitioning analysis class II (91.3%). The synchronous metastasis was found in 6 patients (26.1%) and metachronous metastasis in 17 patients (73.9%). We analyzed the local control rate, intracranial progression-free survival (PFS) and overall survival (OS). Results : The mean tumor volume for GKR was 2.24 cc and the mean prescription dose was 19.4 Gy (range, 10 to 24) to the tumor margin. Out of metachronous metastases, the median duration to intracranial metastasis was 3.3 years in renal cell cancer (RCC), 2.4 years in melanoma and 1.1 years in sarcoma (p=0.012). The total local control rate was 89.6% during the mean 12.4 months follow-up. The six-month and one-year local control rate was 90.2% and 83% respectively. Depending on the pathology, the control rate of RCC was 95.7%, sarcoma 91.3% and melanoma 80.5% during the follow-up. The common cause of local failure was the tumor bleeding in melanoma. The median PFS and OS were 5.2 and 8.4 months in RCC patients, 6.5 and 9.8 months in sarcoma, and 3.8 and 5.1 months in melanoma. Conclusion : The GKR can be one of the effective management options for the intracranial metastatic tumors from the radioresistant tumors. The melanoma showed a poor local control rate compared to other pathologies because of the hemorrhage.
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참고문헌 (17)
참고문헌 신청
Brown PD / 2002 / Stereotactic radiosurgery for patients with “radioresistant” brain metastases / Neurosurgery 51:656~665
Chang EL / 2005 / Outcome variation among “radioresistant” brain metastases treated with stereotactic radiosurgery / Neurosurgery 56:936~945
Clarke JW / 2010 / Stereotactic radiosurgery with or without whole brain radiotherapy for patients with a single radioresistant brain metastasis / Am J Clin Oncol 33:70~74
Coia LR / 1992 / The role of radiation therapy in the treatment of brain metastases / Int J Radiat Oncol Biol Phys 23:229~238
Gaspar L / 1997 / Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials / Int J Radiat Oncol Biol Phys 37:745~751
Chang EL / 2005 / Outcome variation among “radioresistant” brain metastases treated with stereotactic radiosurgery / Neurosurgery 56:936~945
Clarke JW / 2010 / Stereotactic radiosurgery with or without whole brain radiotherapy for patients with a single radioresistant brain metastasis / Am J Clin Oncol 33:70~74
Coia LR / 1992 / The role of radiation therapy in the treatment of brain metastases / Int J Radiat Oncol Biol Phys 23:229~238
Gaspar L / 1997 / Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials / Int J Radiat Oncol Biol Phys 37:745~751
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