지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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A cell-free extract of Saccharomyces cerevisiae containing the angiotensin I-converting enzyme (ACE) inhibitory peptide was treated in a successive simulated gastric-intestinal bioreactor (step 1: amylase digestion, step 2: gastric fluid digestion, step 3: intestinal fluid digestion) to illustrate the absorption pattern of antihypertensive ACE inhibitory peptide, and the ACE inhibitory activities of each step were determined. Total ACE inhibitory activities of step 1, step 2, and step 3 were 55.96%, 80.09%, and 76.77%, respectively. The peptide sequence of each steps was analyzed by MS/MS spectrophotometry. Eleven kinds of representative peptide sequences were conserved in each step, and representative new peptides including RLPTESVPEPK were identified in step 3.
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참고문헌 (10)
참고문헌 신청
Fujita H / 2000 / Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins / J Food Sci 65:564~569
Folkow B / 1961 / The comparative effects of angiotensin and noradrenaline on consecutive vascular sections / Acta Physiol Scand 53:99~104
Ondetti MA / 1982 / Enzymes of the rennin-angiotensin system and their inhibitors / Annu Rev Biochem 51:283~308
Ondetti MA / 1977 / Design of specific inhibitors of angiotensin converting enzyme: new class of orally active antihypertensive agent / Science 196:441~444
KOO, KYO-CHUL / 2006 / Production and Characterization of Antihypertensive Angiotensin I-ConvertingEnzyme Inhibitor from Pholiota adiposa / Journal of Microbiology and Biotechnology 16(5):757~763
Folkow B / 1961 / The comparative effects of angiotensin and noradrenaline on consecutive vascular sections / Acta Physiol Scand 53:99~104
Ondetti MA / 1982 / Enzymes of the rennin-angiotensin system and their inhibitors / Annu Rev Biochem 51:283~308
Ondetti MA / 1977 / Design of specific inhibitors of angiotensin converting enzyme: new class of orally active antihypertensive agent / Science 196:441~444
KOO, KYO-CHUL / 2006 / Production and Characterization of Antihypertensive Angiotensin I-ConvertingEnzyme Inhibitor from Pholiota adiposa / Journal of Microbiology and Biotechnology 16(5):757~763
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