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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 157 - 165 (9page)
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Objective : We have introduced a method of characterization of invading glioma cells by using molecular analysis of marginal invading tumor cells and molecular profiles of glioma tumor margin. Methods : Each of tumor core and marginal tissues was obtained in 22 glioma patients. Tumor core cells and marginal cells from each glial tumor were collected by laser capture microdissection or intraoperative microdissection under the operating microscope. Expression of MMP-2, MMP-9, CD44 and RHAMM mRNA by invading glioma cells compared with tumor core was confirmed by realtime-PCR of twenty-four glioma specimens. Clinical data also were reviewed for invasion and recurrence pattern of the gliomas radiologically and invasive rim pattern microscopically. Results : Overall results of the molecular analysis showed that relative overexpression of MMP-2, MMP-9 and RHAMM were noted at the invasive edge of human glioma specimens comparing to the tumor core but CD44 was highly expressed in the tumor core comparing to the margin. High marginal expression of MMP-2 and MMP-9 were noted in poorly ill-defined margin on the pathological finding. High marginal expression of CD44 and MMP-2 were demonstrated in the midline cross group on the radiological review, and that of RHAMM and MMP-2 were showed in the aggressive recurrence group. High expression of MMP-2 seems to be involved in the various invasion-related phenomenons. Conclusion : Up-regulation of MMP-2, MMP-9, CD44 and RHAMM was noted in invasive edge of gliomas according to the various clinical situations.
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참고문헌 (52)
참고문헌 신청
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Bachelder RE / 1999 / Activation of p53 function in carcinoma cells by the alpha6beta4 integrin / J Biol Chem 274:20733~20737
Berens ME / 1999 / .. those left behind Biology and oncology of invasive glioma cells / Neoplasia 1:208~219
Bignami A / 1992 / Some observations on the localization of hyaluronic acid in adult, newborn and embryonal rat brain / Int J Dev Neurosci 10:45~57
Bignami A / 1993 / Hyaluronic acid and hyaluronic acid binding proteins in brain extracellular matrix / Anat Embryol (Berl) 188:419~433
Bachelder RE / 1999 / Activation of p53 function in carcinoma cells by the alpha6beta4 integrin / J Biol Chem 274:20733~20737
Berens ME / 1999 / .. those left behind Biology and oncology of invasive glioma cells / Neoplasia 1:208~219
Bignami A / 1992 / Some observations on the localization of hyaluronic acid in adult, newborn and embryonal rat brain / Int J Dev Neurosci 10:45~57
Bignami A / 1993 / Hyaluronic acid and hyaluronic acid binding proteins in brain extracellular matrix / Anat Embryol (Berl) 188:419~433
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