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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 235 - 242 (8page)
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In contrast to the nuclear genome, the mitochondrial genome does not follow Mendelian laws of inheritance. The nuclear genome of meiotic progeny comes from the recombination of both parental genomes, whereas the meiotic progeny could inherit mitochondria from one, the other, or both parents. In fact, one fascinating phenomenon is that mitochondrial DNA in the majority of eukaryotes is inherited from only one particular parent. Typically, such unidirectional and uniparental inheritance of mitochondrial DNA can be explained by the size of the gametes involved in mating, with the larger gamete contributing towards mitochondrial DNA inheritance. However, in the human fungal pathogen Cryptococcus neoformans, bisexual mating involves the fusion of two isogamous cells of mating type (MAT) a and MAT${\alpha}$, yet the mitochondrial DNA is inherited predominantly from the MATa parent. Although the exact mechanism underlying such uniparental mitochondrial inheritance in this fungus is still unclear, various hypotheses have been proposed. Elucidating the mechanism of mitochondrial inheritance in this clinically important and genetically amenable eukaryotic microbe will yield insights into general mechanisms that are likely conserved in higher eukaryotes. In this review, we highlight studies on Cryptococcus mitochondrial inheritance and point out some important questions that need to be addressed in the future.
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참고문헌 (48)
참고문헌 신청
Chen XJ / 2005 / The organization and inheritance of the mitochondrial genome / Nat Rev Genet 6:815~825
Westermann B / 2010 / Mitochondrial fusion and fission in cell life and death / Nat Rev Mol Cell Biol 11:872~884
Basse CW / 2010 / Mitochondrial inheritance in fungi / Curr Opin Microbiol 13:712~719
Schapira AH / 2006 / Mitochondrial disease / Lancet 368:70~82
Birky CW Jr / 1995 / Uniparental inheritance of mitochondrial and chloroplast genes: mechanisms and evolution / Proc Natl Acad Sci U S A 92:11331~11338
Westermann B / 2010 / Mitochondrial fusion and fission in cell life and death / Nat Rev Mol Cell Biol 11:872~884
Basse CW / 2010 / Mitochondrial inheritance in fungi / Curr Opin Microbiol 13:712~719
Schapira AH / 2006 / Mitochondrial disease / Lancet 368:70~82
Birky CW Jr / 1995 / Uniparental inheritance of mitochondrial and chloroplast genes: mechanisms and evolution / Proc Natl Acad Sci U S A 92:11331~11338
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