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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 243 - 248 (6page)
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The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 ubiquitin ligases that transfer ubiquitin to the substrates that are subjected to degradation in the 26S proteasome. The Skp1, Cullin, F-box protein (SCF) E3 ligases are the largest E3 gene family, in which the F-box protein is the key component to determine substrate specificity. Although the SCF E3 ligase and its F-box proteins have been extensively studied in the model yeast Saccharomyces cerevisiae, only limited studies have been reported on the role of F-box proteins in other fungi. Recently, a number of studies revealed that F-box proteins are required for fungal pathogenicity. In this communication, we review the current understanding of F-box proteins in pathogenic fungi.
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참고문헌 (44)
참고문헌 신청
Lecker SH / 2006 / Protein degradation by the ubiquitin-proteasome pathway in normal and disease states / J Am Soc Nephrol 17:1807~1819
Baehrecke EH / 2005 / Autophagy: dual roles in life and death / Nat Rev Mol Cell Biol 6:505~510
Glickman MH / 2002 / The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction / Physiol Rev 82:373~428
Hershko A / 1998 / The ubiquitin system / Annu Rev Biochem 67:425~479
Spruck CH / 2002 / Seek and destroy: SCF ubiquitin ligases in mammalian cell cycle control / Cell Cycle 1:250~254
Baehrecke EH / 2005 / Autophagy: dual roles in life and death / Nat Rev Mol Cell Biol 6:505~510
Glickman MH / 2002 / The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction / Physiol Rev 82:373~428
Hershko A / 1998 / The ubiquitin system / Annu Rev Biochem 67:425~479
Spruck CH / 2002 / Seek and destroy: SCF ubiquitin ligases in mammalian cell cycle control / Cell Cycle 1:250~254
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