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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 131 - 136 (6page)
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The basidiomycete Laetiporus sulphureus var. miniatus belongs to the Aphyllophorales, Polyporaceae, and grows on the needleleaf tree. The fruiting bodies of Laetiporus species are known to produce N-methylated tyramine derivatives, polysaccharides, and various lanostane triterpenoids. As part of our ongoing effort to discover biologically active compounds from wood-rotting fungi, an anti-inflammatory triterpene, LSM-H7, has been isolated from the fruiting body of L. sulphureus var. miniatus and identified as acetyl eburicoic acid. LSM-H7 dose-dependently inhibited the NO production in RAW 264.7 cells without any cytotoxicity at the tested concentrations. Furthermore it suppressed the production of proinflammatory cytokines, mainly inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-$1{\beta}$, IL-6 and tumor necrosis factor ${\alpha}$, when compared with glyceraldehyde 3-phosphate dehydrogenase. These data suggest that LSM-H7 is a crucial component for the anti-inflammatory activity of L. sulphureus var. miniatus.
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참고문헌 (23)
참고문헌 신청
Mattila P / 2002 / Basic composition and amino acid contents of mushrooms cultivated in Finland / J Agric Food Chem 50:6419~6422
Borchers AT / 2008 / The immunobiology of mushrooms / Exp Biol Med 233:259~276
Yang N / 2005 / Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita / J Biochem 138:145~150
Jeurink PV / 2008 / Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells / Int Immunopharmacol 8:1124~1133
Dinarello CA / 2000 / Proinflammatory cytokines / Chest 118:503~508
Borchers AT / 2008 / The immunobiology of mushrooms / Exp Biol Med 233:259~276
Yang N / 2005 / Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita / J Biochem 138:145~150
Jeurink PV / 2008 / Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells / Int Immunopharmacol 8:1124~1133
Dinarello CA / 2000 / Proinflammatory cytokines / Chest 118:503~508
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