지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 142 - 144 (3page)
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초록· 키워드
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During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to $^1H$ NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with $IC_{50}$ values of 13.1 and 0.03 ${\mu}M$, respectively.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Zhu T / 2008 / A medicinal mushroom: Phellinus linteus / Curr Med Chem 15:1330~1335
Lee IK / 201105 / Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance / JOURNAL OF ANTIBIOTICS 64(5):349~359
Lee YS / 2010 / Anti-angiogenic activity of methanol extract of Phellinus linteus and its fractions / J Ethnopharmacol 131:56~62
Kim HG / 2007 / Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-κB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage / J Ethnopharmacol 114:307~315
Ichinohe T / 2010 / Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia / J Med Virol 82:128~137
Lee IK / 201105 / Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance / JOURNAL OF ANTIBIOTICS 64(5):349~359
Lee YS / 2010 / Anti-angiogenic activity of methanol extract of Phellinus linteus and its fractions / J Ethnopharmacol 131:56~62
Kim HG / 2007 / Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-κB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage / J Ethnopharmacol 114:307~315
Ichinohe T / 2010 / Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia / J Med Virol 82:128~137
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