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자료유형
학술저널
저자정보
Mishra, Anand P. (Bio-coordination Laboratories, Department of Chemistry, Dr. H.S. Gour Central University) Mishra, Rudra (Bio-coordination Laboratories, Department of Chemistry, Dr. H.S. Gour Central University) Jain, Rajendra (Bio-coordination Laboratories, Department of Chemistry, Dr. H.S. Gour Central University) Gupta, Santosh (Bio-coordination Laboratories, Department of Chemistry, Dr. H.S. Gour Central University)
저널정보
한국균학회 Mycobiology Mycobiology 제40권 제1호
발행연도
2012.1
수록면
20 - 26 (7page)

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The complexes of tailor made ligands with life essential metal ions may be an emerging area to answer the problems of multi drug resistance. The coordination complexes of VO(II), Co(II), Ni(II) and Cu(II) with the Schiff bases derived from isatin with 3-chloro-4-floroaniline and 2-pyridinecarboxaldehyde with 4-aminoantipyrine have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, molar conductance, electronic spectra, FT-IR, FAB mass and magnetic susceptibility measurements. FAB mass data show degradation of complexes. Both the ligands behave as bidentate and tridentate coordinating through O and N donor. The complexes exhibit coordination number 4, 5 or 6. The Schiff base and metal complexes show a good activity against the bacteria; $Staphylococcus$ $aureus$, $Escherichia$ $coli$ and $Streptococcus$ $fecalis$ and fungi $Aspergillus$ $niger$, $Trichoderma$ $polysporum$, $Candida$ $albicans$ and $Aspergillus$ $flavus$. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases. The minimum inhibitory concentrations of the metal complexes were found in the range 10-40 ${\mu}g/mL$.

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