지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 249 - 256 (8page)
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초록· 키워드
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Microorganisms are significantly affected when the ambient pH of their environment changes. They must therefore be able to sense and respond to these changes in order to survive. Previous investigators have studied various fungal species to define conserved pH-responsive signaling pathways. One of these pathways, known as the Pal/Rim pathway, is activated in response to alkaline pH signals, ultimately targeting the PacC/Rim101 transcription factor. Although the central signaling components are conserved among divergent filamentous and yeast-like fungi, there is some degree of signaling specificity between fungal species. This specificity exists primarily in the downstream transcriptional targets of this pathway, likely allowing differential adaptation to species-specific environmental niches. In this review, the role of the Pal/Rim pathway in fungal pH response is discussed. Also highlighted are functional differences present in this pathway among human fungal pathogens, differences that allow these specialized microorganisms to survive in the various micro-environments of the infected human host.
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참고문헌 (53)
참고문헌 신청
Peñalva MA / 2008 / Ambient pH gene regulation in fungi: making connections / Trends Microbiol 16:291~300
Peñalva MA / 2004 / Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts / Annu Rev Microbiol 58:425~451
Arst HN / 2003 / pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems / Trends Genet 19:224~231
Shenoy SK / 2011 / beta-Arrestin-mediated receptor trafficking and signal transduction / Trends Pharmacol Sci 32:521~533
Herrador A / 2010 / Recruitment of the ESCRT machinery to a putative seven-transmembranedomain receptor is mediated by an arrestin-related protein / Mol Cell Biol 30:897~907
Peñalva MA / 2004 / Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts / Annu Rev Microbiol 58:425~451
Arst HN / 2003 / pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems / Trends Genet 19:224~231
Shenoy SK / 2011 / beta-Arrestin-mediated receptor trafficking and signal transduction / Trends Pharmacol Sci 32:521~533
Herrador A / 2010 / Recruitment of the ESCRT machinery to a putative seven-transmembranedomain receptor is mediated by an arrestin-related protein / Mol Cell Biol 30:897~907
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