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자료유형
학술저널
저자정보
Kang, Han-Chul (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) Yoon, Sang-Hong (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) Lee, Chang-Muk (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) Roh, Kyung Hee (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration)
저널정보
한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제56권 제1호
발행연도
2013.1
수록면
37 - 42 (6page)

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In eukaryotes, most of the genome are transcribed, however only a small proportion of total transcripts encodes for protein, thus resulting in many of noncoding RNAs. In order to recover DNA damage including DNA double-strand breaks (DSBs) eukaryotes have evolved complex mechanisms and these are processed through coordinated mechanisms of protein sensors, transducers, and effectors including RNAs. During recent years, small RNAs have been increasingly studied and gradually considered as key regulators in various aspects of biology. Upon DNA damage, small RNAs including diRNAs (DSB induced RNA) are generated in both plant and human cell lines. Inhibition of their biogenesis has severe influence on DSB repair system.

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