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자료유형
학술저널
저자정보
Cho, Jung-Keun (Department of Radiological Science, Jeonju University) Park, Ji-Min (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) Jeon, In-Hwa (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) Kim, Hyeon-Soo (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) Jang, Seon-Il (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제54권 제4호
발행연도
2011.1
수록면
583 - 590 (8page)

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Ultraviolet B (UVB) irradiation induces skin damage and inflammation. Persimmon leaf extract (PLE) has traditionally been used for the treatment of acute and chronic diseases in Asia, but there have been no reports on its UVB-protective effects. Thus, protective effects of PLE against UVBinduced inflammations in HaCaT keratinocytes and mice were investigated. In an in vitro study using HaCaT keratinocytes, UVB irradiation decreased cell viability and increased chemokine production. PLE recovered cell viability and suppressed UVB-induced production of monocyte chemotactic protein-1 (CCL2) and cutaneous T cell-attracting chemokine (CCL27). Moreover, oral administration of PLE to UVB-irradiated mice resulted in significant suppression of skin damage. Histological analyses revealed that infiltration of inflammatory cells, especially degranulated mast cells, thickening of the epidermis, and hyperplasia were significantly reduced. PLE treatment suppressed UVB-induced CCL2 and CCL27 expressions in the skin. These results suggest PLE has potential as an effective material for protection against UVB-induced skin inflammation.

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