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논문 기본 정보

자료유형
학술저널
저자정보
Jeong, Rak-Hun (Graduate School of Biotechnology and Graduate School of Oriental Medicinal Materials & Processing, Kyung Hee University) Lee, Dae-Young (Graduate School of Biotechnology and Graduate School of Oriental Medicinal Materials & Processing, Kyung Hee University) Cho, Jin-Gyeong (Graduate School of Biotechnology and Graduate School of Oriental Medicinal Materials & Processing, Kyung Hee University) Lee, Sang-Min (Graduate School of Biotechnology and Graduate School of Oriental Medicinal Materials & Processing, Kyung Hee University) Kang, Hee-Cheol (R&D center, GFC Co., Ltd.) Seo, Woo-Duck (Department of Functional Crop, National Institute of Crop Science, RDA) Kang, Hwang-Won (Department of Functional Crop, National Institute of Crop Science, RDA) Kim, Ji-Young (Graduate School of Biotechnology and Graduate School of Oriental Medicinal Materials & Processing, Kyung Hee University) Baek, Nam-In (Graduate School of Biotechnology and Graduate School of Oriental Medicinal Materials & Processing, Kyung Hee University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제54권 제6호
발행연도
2011.1
수록면
865 - 870 (6page)

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Fresh and chopped aerial parts of $Oryza$ $sativa$ were extracted in 80% aqueous mehthanol, and the concentrated extract was successively partitioned using $n$-hexane, ethyl acetate (EtOAc), $n$-butanol, and $H_2O$. From the EtOAc fraction, a new flavonolignan (2) and a known flavonolignan, salcolin B (1), were isolated through repeated $SiO_2$ and octadecyl silica gel column chromatography. Based on NMR, mass spectrometer, and IR spectroscopic data, the chemical structure of compound (2) was determined to be tricin-4'-$O$-[erythro-${\beta}$-guaiacyl-(7"-$O$-methyl)-glyceryl] ether, which has thus far never been reported and was named salcolin C (2). Salcolin B (1) and salcolin C (2) dose-dependently inhibited nitric oxide production in RAW 264.7 cells with $IC_{50}$ values of $29.8{\pm}0.6$ and $10.8{\pm}1.0{\mu}m$, respectively, without visible toxic effect.

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