지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 559 - 567 (9page)
이용수
초록· 키워드
오류제보하기
Objective : The aim of this study was to evaluate the effect for biodegradable screws containing bone morphogenetic protein-2 (BMP-2) in an osteoporotic rat model. Methods : Twenty-four female Wistar rat (250-300 g, 12 weeks of age) were randomized into four groups. Three groups underwent bilateral ovariectomy (OVX). Biodegradable screws with or without BMP-2 were inserted in the proximal tibia in two implantation groups. The extracted proximal metaphysis of the tibiae were scanned by exo-vivo micro-computed tomography. Evaluated parameters included bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number, trabecular thickness, and trabecular separation (Tb.Sp). The tibia samples were pathologically evaluated by staining with by Hematoxylin and Eosin, and trichrome. Results : Trabecular formation near screw insertion site was evident only in rats receiving BMP-2 screws. BMD and BV/TV significantly differed between controls and the OVX and OVX with screw groups. However, there were no significant differences between control and OVX with screw BMP groups. Tb.Sp significantly differed between control and OVX and OVX with screw groups (p<0.05), and between the OVX and OVX with screw BMP group (p<0.05), with no statistically significant difference between control and OVX with screw BMP groups. Over the 12 weeks after surgery, bone lamellae in direct contact with the screw developed more extensive and thicker trabecular bone around the implant in the OVX with screw BMP group compared to the OVX with screw group. Conclusion : Biodegradable screws containing BMP-2 improve nearby bone conditions and enhance ostoeintegration between the implant and the osteoporotic bone.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Astrand P / 2008 / Implant treatment of patients with edentulous jaws: a 20-year follow-up / Clin Implant Dent Relat Res 10:207~217
Brown KV / 2011 / Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release / Tissue Eng Part A 17:1735~1746
Cho TJ / 2002 / Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing / J Bone Miner Res 17:513~520
최현민 / 2012 / Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2 / Journal of Periodontal & Implant Science 42(4):119~126
Cowan CM / 2007 / MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects / Tissue Eng 13:501~512
Brown KV / 2011 / Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release / Tissue Eng Part A 17:1735~1746
Cho TJ / 2002 / Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing / J Bone Miner Res 17:513~520
최현민 / 2012 / Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2 / Journal of Periodontal & Implant Science 42(4):119~126
Cowan CM / 2007 / MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects / Tissue Eng 13:501~512
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
흑미(Oryza sativa L.) 호분층 추출물이 난소절제 흰쥐의 골밀도 및 골대사 지표에 미치는 영향
생약학회지(Korean Journal of Pharmacognosy)
2015 .06
-
Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw
Journal of Periodontal & Implant Science
2020 .01
-
Difference in Spinal Fusion Process in Osteopenic and Nonosteopenic Living Rat Models Using Serial Microcomputed Tomography
대한신경외과학회지
2017 .01
-
Impact of Screw Diameter and Length on Pedicle Screw Fixation Strength in Osteoporotic Vertebrae: A Finite Element Analysis
Asian Spine Journal
2021 .10
-
Floor-Mounted Robotic Pedicle Screw Placement in Lumbar Spine Surgery: An Analysis of 1,050 Screws
Neurospine
2023 .06
-
나사 파단 예방을 위해 새로 디자인한 경비 인대 결합 나사의 효용성: 생역학 연구
대한족부족관절학회지
2020 .01
-
An Innovative Universal Screw Removal Instrument
Neurospine
2015 .01
-
Comparison of the Pullout Strength of Different Pedicle Screw Designs and Augmentation Techniques in an Osteoporotic Bone Model
Asian Spine Journal
2018 .01
-
Comparative Analysis of Effect of Density, Insertion Angle and Reinsertion on Pull-Out Strength of Single and Two Pedicle Screw Constructs Using Synthetic Bone Model
Asian Spine Journal
2016 .01
-
Effect of Intermittent Parathyroid Hormone Administration on the Microstructure of Jaw Bone in the Ovariectomized Rats
Journal of Korean Dental Science
2015 .12
-
Fixation Strength of Caudal Pedicle Screws after Posterior Lumbar Interbody Fusion with the Modified Cortical Bone Trajectory Screw Method
Asian Spine Journal
2016 .01
-
A Prospective Study on the Feasibility, Safety, and Efficacy of a Modified Technique to Augment the Strength of Pedicle Screw in Osteoporotic Spine Fixation
Asian Spine Journal
2020 .01
-
Stepwise verification of bone regeneration using recombinant human bone morphogenetic protein-2 in rat fibula model
대한구강악안면외과학회지
2017 .01
-
Favorable effects of ginseng berry aqueous extracts on the ovariectomy-induced osteoporosis in mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
An Ovariectomy-Induced Rabbit Osteoporotic Model: A New Perspective
Asian Spine Journal
2018 .01
-
The effect of Puerariae Radix on ovariectomy-induced bone loss in C3H/ HeN mice
Journal of Biomedical and Translational Research
2018 .12
-
Lateral Mass Screw Fixation in the Cervical Spine: Introducing a New Technique
Asian Spine Journal
2021 .12
-
Freehand S2 Alar-Iliac Screw Placement Using K-Wire and Cannulated Screw : Technical Case Series
대한신경외과학회지
2018 .01
-
Simultaneous Use of Both Bilateral Intralaminar and Pedicle Screws for C2 Stabilization
Asian Spine Journal
2015 .01
-
A Computed Tomography-Based Assessment of the Anatomical Parameters Concerning S2-Alar Iliac Screw Insertion Using “Safe Trajectory Method” in Indian Population
Asian Spine Journal
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0