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논문 기본 정보

자료유형
학술저널
저자정보
Rim, Kyung-Taek (Center for Chemical Safety and Health, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) Kim, Hyeon-Yeong (Center for Chemical Safety and Health, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) Chung, Yong-Hyun (Center for Chemical Safety and Health, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
저널정보
한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제56권 제4호
발행연도
2013.1
수록면
191 - 197 (7page)

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초록· 키워드

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To classify the chemical hazard according to globally harmonized system of classification and labeling of chemicals (GHS), we investigated the genotoxicity of three chemicals, methyl myristate, 2-ethylhexanoic acid zinc salt, N,N,N',N'-tetrakis(2-hydroxyethyl) ethylenediamine, using male ICR mice bone marrow cells for the screening of micronucleus induction. Although these three chemicals have already been tested numerous times, a micronucleus test has not been conducted. The seven week-old male ICR mice were tested at three dosages for the three chemicals, respectively. After 24 h of oral administration with the three chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes, all treated groups expressed no statistically significant increase of MNPCE compared to the negative control group. There were no clinical signs related with the oral exposure of these three chemicals. It was concluded that these three chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and there was no direct proportion with dosage. These results indicate that the three chemicals have no mutagenic potential under each test condition, and it is not classified these chemicals as mutagens by GHS.
#globally harmonized system of classification and labeling of chemicals #methyl myristate #micronucleus #mutagenicity #N,N,N',N'-tetrakis #2-hydroxyethyl) ethylenediamine #2-ethylhexanoic acid zinc salt

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참고문헌 (24)

참고문헌 신청
Brusick DJ / 2008 / Chapter 23: Genetic toxicology, In Principles and Methods of Toxicology / Informa Healthcare USA Inc :1195~1196 google schola Combes R / 2007 / Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH legislation / Altern Lab Anim 35:267~287 google schola Dunnett CW / 1955 / A multiple comparisons procedure several treatments with a control / J Am Stat Assoc 50:1096~1121 google schola Dunnett CW / 1964 / New tables for multiple comparisons with a control / Biometrics 20:482~491 google schola ECVAM / 2002 / Genotoxicity and carcinogenicity / Altern Lab Anim 30(1):83~93 google schola

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