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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Eun-Kyung (Department of Biotechnology, Konkuk University) Kim, Yon-Suk (Department of Biotechnology, Konkuk University) Lee, Seung-Jae (Department of Biotechnology, Konkuk University) Jeon, You-Jin (Faculty of Applied Marine Science, Cheju National University) Ahn, Chang-Bum (Division of Food Science and Aqualife Medicine, Chonnam National University) Kim, Yong-Tae (Department of Food Science & Biotechnology, Kunsan National University) Kang, Hyun (Department of Biotechnology, Konkuk University) Jeong, Jae-Hyun (Department of Food Science & Biotechnology, Chungju National University) Moon, Sang-Ho (Korean Nokyong Research Center, Konkuk University) Jeon, Byong-Tae (Korean Nokyong Research Center, Konkuk University) Park, Pyo-Jam (Department of Biotechnology, Konkuk University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제54권 제1호
발행연도
2011.1
수록면
59 - 65 (7page)

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초록· 키워드

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Anticancer effects of the mussel (Mytilus coruscus) cultivated in Korea were determined. Lipid extracts of Mytilus coruscus were prepared using extractions in several organic solvents: methanol, chloroform, hexane, methanol:chloroform=1:1, and chloroform:hexane=1:1. Anticancer activities of the extracts were evaluated using apoptosis assays analyzed by flow cytometry. The hexane extract exhibited the highest anticancer activity. This extract was further separated and purified using thin layer chromatography, through which lipid compounds were isolated, and their components were analyzed; the major fatty acids were eiocosadienoic acid (EA, C20:2), eicosapentaenoic acid (EPA, C20:5), and docosahexaenoic acid (DHA, C22:6), and these components were higher than those of the mussels cultivated in New Zealand and Italy. The partially purified lipid compounds exhibited an anticancer effect in several cancer cell lines. These results indicate that lipid extract of M. coruscus effectively inhibits in vitro tumor growth by inducing apoptosis of cancer cells.

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