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- 자료유형
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- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제55권 제1호
- 발행연도
- 2012.1
- 수록면
- 1 - 5 (5page)
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Recently, we reported that Jeju ground water contains vanadium components and exerts antioxidant effects in vitro and in vivo via the scavenging of reactive oxygen species and enhancement of antioxidant enzyme activities. In the present study, the antioxidant actions of Jeju ground water were compared with those of tap water against gamma-ray radiation in mice. C57BL/6 mice were irradiated with gamma-ray at a dose rate of 2 Gy. The mice were then given tap water or Jeju ground water for 90 days. Jeju ground water compared with tap water enhanced the activities and levels of superoxide dismutase, catalase, and glutathione peroxidase in irradiated liver tissues. Jeju ground water also enhanced the levels of intracellular reduced glutathione, which is vital for normal liver function and repair. These results suggest that vanadium-containing Jeju ground water can safeguard against the harmful actions of gamma-ray radiation through the support of hepatic antioxidant processes.
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참고문헌 (32)
참고문헌 신청
Arora R / 2005 / Radioprotection by plantproducts: present status and future prospects / Phytother Res 19:1~22
Badmaev V / 1999 / Vanadium: A review of its potential role in the fight against diabetes / J Altern Complement Med 5:273~291
Bakhtiar R / 1999 / Pharmacological applications of inorganic complexes / Gen Pharmacol 32:525~540
Barker S / 2005 / Identification of mammalian proteins cross-linked to DNA by ionizing radiation / J Biol Chem 280:33826~33838
Ceballos-Picot I / 1992 / Age-correlated modifications of copper-zinc superoxide dismutase and glutathione-related enzyme activities in human erythrocytes / Clin Chem 38:66~70
Badmaev V / 1999 / Vanadium: A review of its potential role in the fight against diabetes / J Altern Complement Med 5:273~291
Bakhtiar R / 1999 / Pharmacological applications of inorganic complexes / Gen Pharmacol 32:525~540
Barker S / 2005 / Identification of mammalian proteins cross-linked to DNA by ionizing radiation / J Biol Chem 280:33826~33838
Ceballos-Picot I / 1992 / Age-correlated modifications of copper-zinc superoxide dismutase and glutathione-related enzyme activities in human erythrocytes / Clin Chem 38:66~70
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