지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 944 - 948 (5page)
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초록· 키워드
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We recently demonstrated that the administration of probiotics resulted in a significantly reduced occurrence of atopic dermatitis in infants with high allergic risk. Therefore, the underlying immunological effects that are associated with these apparent clinical benefits were determined. In a randomized, double-blind, placebo-controlled trial, the pregnant women and their infants with a family history of allergic diseases were supplemented with either probiotics (mixture of $Bifidobacterium$ $bifidum$ BGN4, $Bifidobacterium$ $lactis$ AD011, and $Lactobacillus$ $acidophilus$ AD031) or placebo once daily from 4-8 weeks before delivery to 6 months of infants' age. At 1 year of age, the levels of transforming growth factor (TGF)-${\beta}$ produced by peripheral blood monuclear cells from infants fed probiotics were significantly increased compared with those from infants fed placebo ($p$=0.042). Thus, reduction of atopic dermatitis prevalence with probiotics supplementation was associated with significant increases in the capacity of TGF-${\beta}$ responses.
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