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자료유형
학술저널
저자정보
Kim, Jong-Im (Department of Nursing, Jungwon University) Choi, Hwa-Jung (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine) Lee, Jae-Sook (Department of Beauty Science, Kwangju Women's University)
저널정보
한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제56권 제1호
발행연도
2013.1
수록면
49 - 51 (3page)

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In a previous study, we reported that 13(E)-labd-13-ene-$8{\alpha}$,15-diol (13E) possesses antiviral and anticancer activities. In this study, the anticancer and antimicrobial activities of 13(E) were evaluated against 4 cancer cell lines and 6 bacteria. 13(E) showed inhibitory effect on a variety of cancer cell lines. The $IC_{50}$ values was 8.3-21.3 ${\mu}g/mL$. 13(E) was the most effective growth inhibitor of murine leukaemia cell lines P388, producing approximately 8.3 ${\mu}g/mL$ of $IC_{50}$ in the cytopathic effect (CPE) method. 13(E) also inhibited the growth of the gram-positive bacteria (Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria were more sensitive to the compound (MIC, 0.092 mg/mL).

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