지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제53권 제3호
- 발행연도
- 2010.1
- 수록면
- 147 - 153 (7page)
이용수
초록· 키워드
오류제보하기
$\beta$-glycyrrhetinic acid (GA), the active principle of licorice (Glycyrrhiza glabra L.) has been reported to exhibit anti-inflammatory properties in different animal models. In this study, the effects of GA on the production of inflammatory mediators including tumor necrosis factor (TNF)-$\alpha$, interleukin (IL)-6, nitric oxide (NO), and prostaglandin E (pGE)-2 were examined in RAW 264.7 cells in vitro. Furthermore, to elucidate a possible mechanism for the inhibitory effect of GA on the production of TNF-$\alpha$, it was investigated whether the treatment of GA affects the I-${\kappa}B{\alpha}$ degradation and subsequent nuclear translocation of NF-${\kappa}B$. Various inflammatory responses were induced in the culture system by treating with a lipopolysaccharide (LPS). GA showed anti-inflammatory activities in dose-dependant manner with $IC_{50}$ of $5.4{\mu}M$ by inhibiting the production of TNF-$\alpha$ in RAW 264.7 cells. In addition, the treatment of GA blocked both I-${\kappa}B{\alpha}$ degradation and the nuclear translocation of NF-${\kappa}B$ from cytosol to nucleus. However, it did not affect the production of IL-6, NO, and PGE-2, implying the direct blocking of the production of TNF-$\alpha$ resulting from both the I-${\kappa}B{\alpha}$ degradation and the nuclear translocation of NF-${\kappa}B$. This finding might provide the underlying mechanism to explain the reported anti-inflammatory activities of GA in animal models.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Glycyrrhetinic Acid Inhibits Cell Growth and Proliferation, and Induces Apoptosis in Human Gingival Fibroblasts
Food Science and Biotechnology
2002 .10
-
Anti-Inflammatory Effect of Gallic Acid in LPS-Stimulated RAW 264.7 Cells
한국식품영양과학회 학술대회발표집
2011 .10
-
Glycyrrhizic acid 와 Glycyrrhetinic acid의 열분해에 관한 연구
한국연초학회지
1986 .01
-
The inflammatory activity of purified-ferulic acid from Tetragonia tetragonioides
Journal of applied biological chemistry
2019 .01
-
Anti-inflammatory Activity of Catechol and Ferulic acid Derivatives in Raw264.7 Cells
한국식품영양과학회 학술대회발표집
2013 .11
-
Anti-Microbial and Anti-Inflammatory Effects of Differently Prepared-Dead Cells from Lactic Acid Bacteria
한국식품영양과학회 학술대회발표집
2018 .10
-
Anti-inflammatory Effects of Korean Propolis Extracts on Raw264.7 Macrophage Cells
한국식품영양과학회 학술대회발표집
2018 .10
-
Lipopolysaccharide로 유도된 Raw 264.7 cell에서 물레나물(Hypericum asctron)의 Pro-inflammatory 억제 효과
Journal of applied biological chemistry
2017 .01
-
Anti-inflammatory effect of water extract from skipjack tuna heart on lipopolysaccharide induced inflammatory responses in RAW 264.7 cells
한국수산과학회 양식분과 학술대회
2015 .10
-
Anti-inflammatory Effects of Curcuma longa L. Extracts on RAW 264.7 Cells
한국식품영양과학회 학술대회발표집
2014 .10
-
Anti-inflammatory Activity of the Rice Germ Oil in LPS-induced RAW 264.7 Cells
한국식품영양과학회 학술대회발표집
2013 .11
-
Anti-Oxidative and Anti-Inflammatory Effects of Medicinal Herb Extracts
한국식품영양과학회 학술대회발표집
2019 .10
-
In vitro Anti-inflammatory Activity of CT extracts in Murine Macrophage RAW264,7 Cells
한국식품영양과학회 학술대회발표집
2011 .10
-
Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells
Applied Biological Chemistry
2016 .01
-
Anti-inflammatory Activity of Tuna Oil in LPS-induced RAW264.7 cells and Mouse
한국식품영양과학회 학술대회발표집
2014 .10
-
Anti-inflammatory Activity of Korean Native Chrysanthemum Extracts in RAW 264.7 Macrophages
한국원예학회 학술발표요지
2011 .05
-
Mechanisms of Anti-Obesity and Anti-Inflammatory Effects of Omega 3 Fatty Acids in Adipose Tissue
한국식품영양과학회 학술대회발표집
2016 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0