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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제54권 제1호
- 발행연도
- 2011.1
- 수록면
- 63 - 66 (4page)
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초록· 키워드
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The bark of Machilus thunbergii was extracted with 80% aqueous methanol (MeOH), and the concentrated extract was partitioned using ethyl acetate (EtOAc), butanol (n-BuOH), and $H_2O$, successively. From the EtOAc fraction, five lignans were isolated through the repeated silica gel, octadecyl silica gel (ODS) and, Sephadex LH-20 column chromatography. Based on nuclear magnetic resonance (NMR), mass spectroscopy (MS), and infrared spectroscopy (IR) spectroscopic data, the chemical structures of the compounds were determined to be machilin A (1), machilin F (2), licarin A (3), nectandrin A (4), and nectandrin B, (5). This study presents comparative account of five lignans from M. thunbergii bark contributing inhibition of low density lipoprotein (LDL), ACAT-1, and ACAT-2. Compounds 2-5 showed varied degree of antioxidant activity on LDL with $IC_{50}$ values of 2.1, 11.8, 15.3, and $4.1{\mu}M$. Compounds 1, 2, and 3 showed inhibition activity on ACAT-1 with values $63.4{\pm}6.9%$ ($IC_{50}=66.8{\mu}M$), $53.7{\pm}0.9%$ ($IC_{50}=109.2{\mu}M$), and $78.7{\pm}0.2%$ ($IC_{50}=40.6{\mu}M$), respectively, at a concentration of 50 mg/mL, and on ACAT-2 with values $47.3{\pm}1.5%$ ($IC_{50}=149.7{\mu}M$), $39.2{\pm}0.2%$ ($IC_{50}=165.2{\mu}M$), and $52.1{\pm}1.0%$ ($IC_{50}=131.0{\mu}M$, respectively, at a concentration of 50 mg/mL.
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참고문헌 (25)
참고문헌 신청
Ahn BT / 2001 / Low-density lipoprotein-antioxidant constituents of Saururus chinensis / J Nat Prod 64:1562~1564
Mi-Young Baek / 2010 / Isolation of Triterpenoids from the Stem Bark of Albizia julibrissin and Their Inhibition Activity on ACAT-1 and ACAT-2 / Journal of the Korean Society for Applied Biological Chemistry 53(3):310~315
Brecher P / 1980 / Properties of acyl-CoA: cholesterol acyltransferase in aortic microsomes from atherosclerotic rabbits / Biochim Biophys Acta 617:458~471
Chung BS / 2000 / Dictionary of Korean Folk Medicine / Young Lim Sa
Diaz MN / 1997 / Antioxidants and atherosclerotic heart disease / N Engl J Med 337:408~416
Mi-Young Baek / 2010 / Isolation of Triterpenoids from the Stem Bark of Albizia julibrissin and Their Inhibition Activity on ACAT-1 and ACAT-2 / Journal of the Korean Society for Applied Biological Chemistry 53(3):310~315
Brecher P / 1980 / Properties of acyl-CoA: cholesterol acyltransferase in aortic microsomes from atherosclerotic rabbits / Biochim Biophys Acta 617:458~471
Chung BS / 2000 / Dictionary of Korean Folk Medicine / Young Lim Sa
Diaz MN / 1997 / Antioxidants and atherosclerotic heart disease / N Engl J Med 337:408~416
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