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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 66 - 72 (7page)
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초록· 키워드
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Preliminary data show that hydroxyaniline derivatives have strong inhibitory activities against mushroom tyrosinase. Twelve out of thirty-four synthesized hydroxyaniline derivatives demonstrated inhibitory activities, among which ethyl-(4-hydroxyphenyl)oxamate sodium salt (EHPONa) was found to be the most effective inhibitor. Inhibitory activities of hydroxyaniline derivatives were much higher than that of commercially available whitening agent arbutin, and comparable to that of kojic acid. Data showed that EHPONa x had a higher inhibitory activity of melanin biosynthesis than those of both kojic acid and arbutin. Based on the study of inhibition kinetics and cupric chloride effects on enzyme activity, we propose that 4-hydroxyl oxygen and oxamate oxygen moiety of EHPONa chelate the two cupric ions at the active site, and that phenol moiety interacts with the hydrophobic enzyme pocket. Accordingly, EHPONa may be a good candidate as a skin-whitening agent.
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