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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 445 - 454 (10page)
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초록· 키워드
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Objective : In the present study we analyzed neuroprotective and antiapoptotic effect of the difumarate salt S-15176, as an anti-ischemic, an antioxidant and a stabilizer of mitochondrial membrane in secondary damage following spinal cord injury (SCI) in a rat model. Methods : Three groups were performed with 30 Wistar rats; control (1), trauma (2), and a trauma+S-15176 (10 mg/kg i.p., dimethyl sulfoxide) treatment (3). SCI was performed at the thoracic level using the weight-drop technique. Spinal cord tissues were collected following intracardiac perfusion in 3rd and 7th days of posttrauma. Hematoxylin and eosin staining for histopatology, terminal deoxynucleotidyl transferase dUTP nick end labeling assay for apoptotic cells and immunohistochemistry for proapoptotic cytochrome-c, Bax and caspase 9 were performed to all groups. Functional recovery test were applied to each group in 3rd and 7th days following SCI. Results : In trauma group, edematous regions, diffuse hemorrhage, necrosis, leukocyte infiltration and severe degeneration in motor neurons were observed prominently in gray matter. The number of apoptotic cells was significantly higher (p<0.05) than control group. In the S-15176-treated groups, apoptotic cell number in 3rd and 7th days (p<0.001), also cytochrome-c (p<0.001), Bax (p<0.001) and caspase 9 immunoreactive cells (p<0.001) were significantly decreased in number compared to trauma groups. Hemorrhage and edema in the focal areas were also noticed in gray matter of treatment groups. Results of the locomotor test were significantly increased in treatment group (p<0.05) when compared to trauma groups. Conclusion : We suggest that difumarate salt S-15176 prevents mitochondrial pathways of apoptosis and protects spinal cord from secondary injury and helps to preserve motor function following SCI in rats.
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등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Albengres E. / 2001 / S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes / Fundam Clin Pharmacol 15:41~46
Allen AR / 1911 / Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column : a preliminary report / JAMA 57:877~880
Amar AP. / 1999 / Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury / Neurosurgery 44:1027~1039
Basso DM. / 1995 / A sensitive and reliable locomotor rating scale for open field testing in rats / J Neurotrauma 12:1~21
Bernardi P / 1996 / The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death / Biochim Biophys Acta 1275:5~9
Allen AR / 1911 / Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column : a preliminary report / JAMA 57:877~880
Amar AP. / 1999 / Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury / Neurosurgery 44:1027~1039
Basso DM. / 1995 / A sensitive and reliable locomotor rating scale for open field testing in rats / J Neurotrauma 12:1~21
Bernardi P / 1996 / The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death / Biochim Biophys Acta 1275:5~9
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