지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 422 - 427 (6page)
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초록· 키워드
오류제보하기
Moyamoya disease (MMD) is a chronic, progressive, cerebrovascular occlusive disorder that displays various clinical features and results in cerebral infarct or hemorrhagic stroke. Specific genes associated with the disease have not yet been identified, making identification of at-risk patients difficult before clinical manifestation. Familial MMD is not uncommon, with as many as 15% of MMD patients having a family history of the disease, suggesting a genetic etiology. Studies of single nucleotide polymorphisms (SNPs) in MMD have mostly focused on mechanical stress on vessels, endothelium, and the relationship to atherosclerosis. In this review, we discuss SNPs studies targeting the genetic etiology of MMD. Genetic analyses in familial MMD and genome-wide association studies represent promising strategies for elucidating the pathophysiology of this condition. This review also discusses future research directions, not only to offer new insights into the origin of MMD, but also to enhance our understanding of the genetic aspects of MMD. There have been several SNP studies of MMD. Current SNP studies suggest a genetic contribution to MMD, but further reliable and replicable data are needed. A large cohort or family-based design would be important. Modern SNP studies of MMD depend on novel genetic, experimental, and database methods that will hopefully hasten the arrival of a consensus conclusion.
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등록된 정보가 없습니다.
참고문헌 (78)
참고문헌 신청
Achrol AS. / 2009 / Pathophysiology and genetic factors in moyamoya disease / Neurosurg Focus 26:E4
Andreone V. / 1999 / Moyamoya disease in Italian monozygotic twins / Neurology 53:1332~1335
Aoyagi M. / 1991 / Altered cellular responses to serum mitogens, including platelet-derived growth factor, in cultured smooth muscle cells derived from arteries of patients with moyamoya disease / J Cell Physiol 147:191~198
Aoyagi M. / 1995 / Human leukocyte antigen in patients with moyamoya disease / Stroke 26:415~417
Asahi M. / 2001 / Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia / J Neurosci 21:7724~7232
Andreone V. / 1999 / Moyamoya disease in Italian monozygotic twins / Neurology 53:1332~1335
Aoyagi M. / 1991 / Altered cellular responses to serum mitogens, including platelet-derived growth factor, in cultured smooth muscle cells derived from arteries of patients with moyamoya disease / J Cell Physiol 147:191~198
Aoyagi M. / 1995 / Human leukocyte antigen in patients with moyamoya disease / Stroke 26:415~417
Asahi M. / 2001 / Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia / J Neurosci 21:7724~7232
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