지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 19 - 26 (8page)
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There are many cyclic peptides with diverse biological activities, such as antibacterial activity, immunosuppressive activity, and anti-tumor activity, and so on. Encouraged by natural cyclic peptides with biological activity, efforts have been made to develop cyclic peptides with both genetic and synthetic methods. The genetic methods include phage display, intein-based cyclic peptides, and mRNA display. The synthetic methods involve individual synthesis, parallel synthesis, as well as split-and-pool synthesis. Recent development of cyclic peptide library based on split-and-pool synthesis allows on-bead screening, in-solution screening, and microarray screening of cyclic peptides for biological activity. Cyclic peptides will be useful as receptor agonist/antagonist, RNA binding molecule, enzyme inhibitor and so on, and more cyclic peptides will emerge as therapeutic agents and biochemical tools.
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참고문헌 (65)
참고문헌 신청
Athanassiou, Z. / 2004 / Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affi nity and selectivity for viral TAR RNA regulatory elements / J. Am. Chem. Soc 126:6906~6913
Athanassiou, Z. / 2007 / Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodefi ciency virus / Biochemistry 46:741~751
Bu, X. / 2002 / Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution / Org. Lett 4:2893~2895
Colgrave, M. L. / 2010 / Sunfl ower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs / Biopolymers 94:665~672
Dubos, R. J. / 1939 / Studies on a bactericidal agent extracted from a soil bacillus : Iii. preparation and activity of a protein- free fraction / J. Exp. Med 70:249~256
Athanassiou, Z. / 2007 / Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodefi ciency virus / Biochemistry 46:741~751
Bu, X. / 2002 / Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution / Org. Lett 4:2893~2895
Colgrave, M. L. / 2010 / Sunfl ower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs / Biopolymers 94:665~672
Dubos, R. J. / 1939 / Studies on a bactericidal agent extracted from a soil bacillus : Iii. preparation and activity of a protein- free fraction / J. Exp. Med 70:249~256
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