지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 400 - 405 (6page)
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초록· 키워드
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G-protein coupled receptor 119 (GPR119) has emerged as a novel target for the treatment of type 2 diabetes mellitus. GPR119 is involved in glucose-stimulated insulin secretion (GSIS) from the pancreatic b-cells and intestinal cells. In this study, we identified a novel small-molecule GPR119 agonist, HD047703, which raises intracellular cAMP concentrations in pancreatic ${\beta}$-cells and can be expected to potentiate glucose-stimulated insulin secretion from human GPR119 receptor stably expressing cells (CHO cells). We evaluated the acute efficacy of HD047703 by the oral glucose tolerance test (OGTT) in normal C57BL/6J mice. Then, chronic administrations of HD047703 were performed to determine its efficacy in various diabetic rodent models. Single administration of HD047703 caused improved glycemic control during OGTT in a dose-dependent manner in normal mice, and the plasma GLP-1 level was also increased. With respect to chronic efficacy, we observed a decline in blood glucose levels in db/db, ob/ob and DIO mice. These results suggest that HD047703 may be a potentially promising anti-diabetic agent.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Amiel, S. A / 2008 / Hypoglycaemiain type 2 diabetes / Diabet. Med 25:245~254
Barnett, A / 2006 / DPP-4 inhibitors and their potential role in the managementof type 2 diabetes / Int. J. Clin. Pract 60:1454~1470
Barnett, A / 2007 / A reviewof the effects of antihyperglycaemic agents on body weight: Thepotential of incretin targeted therapies / Curr. Med. Res. Opin 23:1493~1507
Bekur, R / 2010 / Sitagliptin-induced hemolysis / Indian J. Pharmacol 42:320~321
Chu, Z. L / 2007 / A role for beta-cell-expressed G protein-coupled receptor 119 inglycemic control by enhancing glucose-dependent insulin release / Endocrinology 148:2601~2609
Barnett, A / 2006 / DPP-4 inhibitors and their potential role in the managementof type 2 diabetes / Int. J. Clin. Pract 60:1454~1470
Barnett, A / 2007 / A reviewof the effects of antihyperglycaemic agents on body weight: Thepotential of incretin targeted therapies / Curr. Med. Res. Opin 23:1493~1507
Bekur, R / 2010 / Sitagliptin-induced hemolysis / Indian J. Pharmacol 42:320~321
Chu, Z. L / 2007 / A role for beta-cell-expressed G protein-coupled receptor 119 inglycemic control by enhancing glucose-dependent insulin release / Endocrinology 148:2601~2609
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