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논문 기본 정보

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학술저널
저자정보
Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Lee, Hyun-A (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Ahn, Joon-Ik (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Jeon, Seol-Hee (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Kim, Eun Jung (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Jeong, Ho-Sang (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safe)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제4호
발행연도
2013.1
수록면
307 - 312 (6page)

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Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.
#Quetiapine #Dopamine system #Serotonin system #Drug dependence #Animal behavioral tests

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참고문헌 (42)

참고문헌 신청
Acheson, S. K. / 1999 / Developmental changes in seizure susceptibility during ethanol withdrawal / Alcohol 18:23~26 google schola Adityanjee / 2002 / Clinical use of quetiapine in disease states other than schizophrenia / J. Clin. Psychiatry 63:32~38 google schola Arango, C. / 2004 / Managing acute exacerbations of schizophrenia: focus on quetiapine / Curr. Med. Res. Opin 20:619~626 google schola Bozarth, M. A. / 1987 / Conditioned place preference: a parametric analysis using system heroin injection. In Methods of assessing the reinforcing properties of abused drugs / Springer :241~273 google schola Brown, E. S. / 2002 / Quetiapine in bipolar disorder and cocaine dependence / Bipolar Disord 4:406~411 google schola

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