지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 739 - 746 (8page)
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초록· 키워드
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To examine the effects of three types of resistant starch (RS) on intestinal metabolites, structure and their gastric injury preventive activities, Sprague-Dawley mice were fed diet containing 15% RS for 4 weeks. Response relationships among three types of RS (RS2, RS3, and RS4) food intake, body weight gain, food efficiency, wet weight of cecum (with or not with contents), pH, ammonia production, and short-chain fatty acids (SCFAs) concentration of cecal contents as well as intestinal structure were investigated. All three types of RS had effects on food intake, weight control, lowering of pH, ammonia production in cecal contents, increasing the wet weight of cecum (with or without contents), changes in SCFAs concentration of cecal contents, and physiological structure of small intestine and cecum compared to the control group (common starch-fed rats). RS3 group showed minimum weight gain and food efficiency, compared to both the control group and the other two types of RS diet. RS3 group showed more significant lowering of pH, ammonia production, and SCFAs of cecal contents. In addition, all three types of RS shortened villous height, and muscle and mucosal thickening in small intestine, resulting in significantly decreased villous height and mucosal thickness, whereas significantly increased muscle thickness in the cecum. However, they did not cause detectable pathological changes in the small intestine and cecum. Animal model was also used to check its gastric ulcer preventive effects. The gastric ulcer level was significantly down-regulated by RS3, demonstrating its anti-inflammatory properties. RS3 reduced the levels of serum proinflammatory cytokines of IL-6, IL-12, TNF-${\alpha}$, and IFN-${\gamma}$ compared to RS2 and RS4. RS3 increased the somatostatin (SS) and vasoactive intestinal peptide (VIP), decreased the motillin (MOT) and substance P (SP) serum levels. These results suggest that RS3 shows the best gastric ulcer preventive effect.
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