지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 368 - 373 (6page)
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초록· 키워드
오류제보하기
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations. In the present study, we examined whether linalool elicited an anti-stress effect, reversing the behavioral alterations observed following REM-sleep deprivation in mice. Furthermore, we investigated the underlying mechanism of the effect of linalool. Spatial memory and learning memory were assessed through Y maze and passive avoidance tests, respectively, and the forced swimming test was used to evaluate anti-stress activity. The mechanisms through which linalool improves memory loss and behavioral alterations in sleep-deprived mice appeared to be through an increase in the serotonin levels. Linalool significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived animals. Moreover, linalool led to serotonin release, and cortisol level reduction. Our findings suggest that linalool has beneficial effects on the memory loss and behavioral alterations induced by REM-sleep deprivation through the regulation of serotonin levels.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Andersen, M. L. / 2005 / Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats / J. Sleep Res. 14:83~90
Anjos, P. J. / 2013 / Cardiovascular effects induced by linalool in normotensive and hypertensive rats / Z. Naturforsch., C, J. Biosci. 68:181~190
June Bryan I. de la Pen˜a / 2014 / Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor / Archives of Pharmacal Research 37(2):263~269
de Lima, M. N. / 2005 / Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats / Behav. Brain Res. 156:139~143
Dimitrov, S. / 2004 / Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans / Brain Behav. Immun. 18:341~348
Anjos, P. J. / 2013 / Cardiovascular effects induced by linalool in normotensive and hypertensive rats / Z. Naturforsch., C, J. Biosci. 68:181~190
June Bryan I. de la Pen˜a / 2014 / Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor / Archives of Pharmacal Research 37(2):263~269
de Lima, M. N. / 2005 / Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats / Behav. Brain Res. 156:139~143
Dimitrov, S. / 2004 / Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans / Brain Behav. Immun. 18:341~348
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