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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 667 - 672 (6page)
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초록· 키워드
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Six known compounds including ${\alpha}$-amyrin 3-acetate (1), ${\beta}$-sitosterol (2), betulinic acid (3), friedelan-3-one (4), artochamin B (5), and 2-C-methyl-D-erythritol 4-O-${\alpha}$-D-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1-6 were evaluated. Results showed that artochamin B (5) possessed the highest cytotoxicity towards MCF7, Lu, HepG2, and KB cell lines with $IC_{50}$ values of 4.59, 20.00, 3.60, and $1.18{\mu}g/mL$, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.
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