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논문 기본 정보

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학술저널
저자정보
Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Lee, Kwang-Wook (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Song, Min-Ji (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Hyeon, Yang-Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Hwang, Ji-Young (School of Pharmacy, Sungkyunkwan University) Jang, Choon-Gon (School of Pharmacy, Sungkyunkwan University) Ahn, Joon-Ik (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Jeon, Seol-Hee (Pharmacological Research Division) Kim, Hyun-Uk Kim, Young-Hoon Seong, Won-Keun Kang, Hoil Yoo, Han Sang Jeong, Ho-Sang
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제22권 제4호
발행연도
2014.1
수록면
363 - 369 (7page)

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Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally under street names such as "Spice" and "Smoke". Many countries including Korea have started to schedule some of the JWH series compounds as controlled substances, but there are a number of JWH series chemicals that remain uncontrolled by law. In this study, three synthetic CBs with different binding affinities to the $CB_1$ receptor (JWH-073, 081, and 210) and ${\Delta}^9$-tetrahydrocannabinol (${\Delta}^9$-THC) were evaluated for their potential for psychological dependence. The conditioned place preference test (unbiased method) and self-administration test (fixed ratio of 1) using rodents were conducted. $K_i$ values of the three synthetic cannabinoids were calculated as supplementary data using a receptor binding assay and overexpressed $CB_1$ protein membranes to compare dependence potential with $CB_1$ receptor binding affinity. All mice administered JWH-073, 081, or 210 showed significantly increased time spent at unpreferred space in a dose-dependence manner in the conditioned place preference test. In contrast, all tested substances except ${\Delta}^9$-THC showed aversion phenomenon at high doses in the conditioned place preference test. The order of affinity to the $CB_1$ receptor in the receptor binding assay was JWH-210 > JWH-081 >> JWH-073, which was in agreement with the results from the conditioned place preference test. However, no change in self-administration was observed. These findings suggest the possibility to predict dependence potential of synthetic CBs through a receptor binding assay at the screening level.
#Synthetic cannabinoid #${Delta}^9$-Tetrahydrocannabinol #${Delta}^9$-THC) #Psychological dependence #$CB_1$ receptor #Binding affinity

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참고문헌 (25)

참고문헌 신청
Alexander, S. P / 2008 / Guide to receptorsand channels (GRAC) / Br. J. Pharmacol 153:S1~S209 google schola Atwood, B. K / 2011 / CP47, 497-C8 and JWH073, commonly found in 'Spice'herbal blends, are potent and effi cacious CB1 cannabinoid receptoragonists / Eur. J. Pharmacol 659:139~145 google schola Aung, M. M / 2000 / Infl uence ofthe N-1 alkyl chain length of cannabimimetic indoles upon CB1 andCB2 receptor binding / Drug Alcohol Depend 60:133~140 google schola Auwarter, V / 2009 / 'Spice' and other herbal blends: harmless incenseor cannabinoid designer drugs / J. Mass Spectrom 44:832~837 google schola Bozarth, M. A / 1987 / Methods of assessingthe reinforcing properties of abused drugs / Springer-Verlag :241~273 google schola

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