지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 308 - 313 (6page)
이용수
초록· 키워드
오류제보하기
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway plays an important role in the transcriptional regulation of AP-1 expression. Although the histone post-translational modifications (PTMs) are assumed to affect the AP-1 transcriptional regulation by the PI3K/Akt pathway, the detailed mechanisms are completely unknown. In the present study, we show that heterochromatin 1 gamma ($HP1{\gamma}$) plays a negative role in TPA-induced c-Jun and c-Fos expression. We show that TPA-induced Akt1 directly phosphorylates $HP1{\gamma}$, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-$3{\varepsilon}$. Collectively, these our data illustrate that the activation of PI3K/Akt pathway may play a permissive role in the recruitment of histone readers or other coactivators on the chromatin, thereby affecting the degree of AP-1 transcription.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Allis, C. D / 2007 / New nomenclature for chromatin-modifying enzymes / Cell 131:633~636
Angel, P / 1991 / The role of Jun, Fos and the AP-1complex in cell-proliferation and transformation / Biochim. Biophys.Acta 1072:129~157
Calixto, J. B / 2004 / Anti-infl ammatory compounds of plant origin. Part II. modulation ofpro-infl ammatory cytokines, chemokines and adhesion molecules / Planta Med 70:93~103
Cardesa, A / 2011 / The Kaiser’s cancer revisited: was Virchow totally wrong / Virchows Arch 458:649~657
Chinenov, Y / 2001 / Close encounters of manykinds: Fos-Jun interactions that mediate transcription regulatoryspecifi city / Oncogene 20:2438~2452
Angel, P / 1991 / The role of Jun, Fos and the AP-1complex in cell-proliferation and transformation / Biochim. Biophys.Acta 1072:129~157
Calixto, J. B / 2004 / Anti-infl ammatory compounds of plant origin. Part II. modulation ofpro-infl ammatory cytokines, chemokines and adhesion molecules / Planta Med 70:93~103
Cardesa, A / 2011 / The Kaiser’s cancer revisited: was Virchow totally wrong / Virchows Arch 458:649~657
Chinenov, Y / 2001 / Close encounters of manykinds: Fos-Jun interactions that mediate transcription regulatoryspecifi city / Oncogene 20:2438~2452
이 논문의 저자 정보
최근 본 자료
댓글(0)
0