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논문 기본 정보

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학술저널
저자정보
Lee, Mee-Hyun (Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University) Kundu, Joydeb Kumar (College of Pharmacy, Keimyung University) Keum, Young-Sam (College of Pharmacy, Dongguk University) Cho, Yong-Yeon (College of Pharmacy, The Catholic University of Korea) Surh, Young-Joon (Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University) Choi, Bu Young (Pharmaceutical Science and Engineering, School of Convergence Bioscience and Technology, Seowon University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제22권 제5호
발행연도
2014.1
수록면
426 - 430 (5page)

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Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional activity of androgen receptor (AR) and/or signal transducer and activator of transcription-3 (STAT3) contributes to the proliferation of prostate cancer cells. In the present study, we examined the effect of resveratrol, a phytoalexin present in grapes, on the reporter gene activity of AR and STAT3 in human prostate cancer (LNCaP-FGC) cells stimulated with interleukin-6 (IL-6) and/or dihydrotestosterone (DHT). Our study revealed that resveratrol suppressed the growth of LNCaP-FGC cells in a time- and concentration-dependent manner. Whereas the AR transcriptional activity was induced by treatment with either IL-6 or DHT, the STAT3 transcriptional activity was induced only by treatment with IL-6 but not with DHT. Resveratrol significantly attenuated IL-6-induced STAT3 transcriptional activity, and DHT- or IL-6-induced AR transcriptional activity. Treatment of cells with DHT plus IL-6 significantly increased the AR transcriptional activity as compared to DHT or IL-6 treatment alone and resveratrol markedly diminished DHT plus IL-6-induced AR transcriptional activity. Furthermore, the production of prostate-specific antigen (PSA) was decreased by resveratrol in the DHT-, IL-6- or DHT plus IL-6-treated LNCaP-FGC cells. Taken together, the inhibitory effects of resveratrol on IL-6- and/or DHT-induced AR transcriptional activity in LNCaP prostate cancer cells are partly mediated through the suppression of STAT3 reporter gene activity, suggesting that resveratrol may be a promising therapeutic choice for the treatment of prostate cancer.
#Resveratrol #AR transcriptional activity #STAT3 transcriptional activity #Prostate cancer

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참고문헌 (20)

참고문헌 신청
Bommareddy, A / 2013 / Chemoprevention of prostatecancer by major dietary phytochemicals / Anticancer Res 33:4163~4174 google schola Chun, J. Y / 2009 / Interleukin-6 regulates androgensynthesis in prostate cancer cells / Clin. Cancer Res 15:4815~4822 google schola Guo, Y / 2012 / Interleukin-6 signalingpathway in targeted therapy for cancer / Cancer Treat. Rev 38:904~910 google schola Ha, S / 2013 / Phosphorylation of the androgen receptor by PIM1 in hormonerefractory prostate cancer / Oncogene 32:3992~4000 google schola Harada, N / 2011 / Inhibitory mechanisms of the transcriptional activity ofandrogen receptor by resveratrol: Implication of DNA binding andacetylation of the receptor / J. Steroid Biochem. Mol. Biol 123:65~70 google schola

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