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논문 기본 정보

자료유형
학술저널
저자정보
Hong, Su Hee (Department of Biochemistry, College of Medicine, Hallym University) Heo, Jee-In (Department of Biochemistry, College of Medicine, Hallym University) Kim, Jeong-Hyeon (Department of Biochemistry, College of Medicine, Hallym University) Kwon, Sang-Oh (S&D Co., Ltd.) Yeo, Kyung-Mok (S&D Co., Ltd.) Bakowska-Barczak, Anna M. (Department of Agricultural, Food and Nutritional Science, University of Alberta) Kolodziejczyk, Paul (Department of Fruit, Vegetable and Cereal Technology, Wroclaw University of Environmental and Life Sciences) Ryu, Ok-Hyun (Department of Internal Medicine, Chuncheon Sacred Heart Hospital/Hallym University Medical Center) Choi, Moon-Ki (Department of Internal Medicine, Chuncheon Sacred Heart Hospital/Hallym University Medical Center) Kang, Young-Hee (Department of Food and Nutrition, College of Natural Sciences, College of Medicine, Hallym University) Lim, Soon Sung (Institute of Natural Medicine, College of Medicine, Hallym University) Suh, Hong-Won (Institute of Natural Medicine, College of Medicine, Hallym University) Huh, Sung-Oh (Institute of Natural Medicine, College of Medicine, Hallym University) Lee, Jae-Yong (Department of Biochemistry, College of Medicine,)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제4호
발행연도
2013.1
수록면
284 - 289 (6page)

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Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.

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