지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 78 - 81 (4page)
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초록· 키워드
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Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using HPLC. The pharmacokinetics of intravenous administered and rectal administered in rabbits was investigated. Following a single intravenous dose of irinotecan (50 mg/kg), the plasma irinotecan concentration demonstrated a bi-exponential decay, with a rapid decline over 15 min. $C_{max}$, $t_{1/2}$, $AUC_{0-30h}$ and $AUC_{0-{\infty}}$ were $16.1{\pm}2.7g/ml$, $7.6{\pm}1.2h$, $71.3{\pm}8.8{\mu}g{\cdot}h/ml$ and $82.3{\pm}9.5{\mu}g{\cdot}h/ml$, respectively. Following rectal administration of 100 mg/kg irinotecan, the plasma irinotecan concentration reached a peak of $5.3{\pm}2.5{\mu}g/ml$ at 4 h. The $AUC_{0-30h}$ and $AUC_{0-{\infty}}$ were $32.2{\pm}6.2{\mu}g{\cdot}h/ml$ and $41.6{\pm}7.2{\mu}g{\cdot}h/ml$, respectively. It representing ~50.6% of the absolute bioavailability.
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참고문헌 (14)
참고문헌 신청
Barth, S. W / 2010 / In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats / Biotechnol. J 5:321~327
Choi, H. G / 1998 / Development of in-situ gelling and mucoadhesive acetaminophenliquid suppository / Int. J. Pharm 165:33~44
Hind, D / 2008 / The use of irinotecan, oxaliplatin and raltitrexed forthe treatment of advanced colorectal cancer: systematic reviewand economic evaluation / Health Technol. Assess 12:3~162
Hirasawa, A / 2013 / Polymorphisms in the UGT1A1gene predict adverse effects of irinotecan in the treatment of gynecologiccancer in Japanese patients / J. Hum. Genet 58:825
Kanzawa, F / 2001 / In vitro synergisticinteractions between the cisplatin analogue nedaplatin andthe DNA topoisomerase I inhibitor irinotecan and the mechanism ofthis interaction / Clin. Cancer Res 7:202~209
Choi, H. G / 1998 / Development of in-situ gelling and mucoadhesive acetaminophenliquid suppository / Int. J. Pharm 165:33~44
Hind, D / 2008 / The use of irinotecan, oxaliplatin and raltitrexed forthe treatment of advanced colorectal cancer: systematic reviewand economic evaluation / Health Technol. Assess 12:3~162
Hirasawa, A / 2013 / Polymorphisms in the UGT1A1gene predict adverse effects of irinotecan in the treatment of gynecologiccancer in Japanese patients / J. Hum. Genet 58:825
Kanzawa, F / 2001 / In vitro synergisticinteractions between the cisplatin analogue nedaplatin andthe DNA topoisomerase I inhibitor irinotecan and the mechanism ofthis interaction / Clin. Cancer Res 7:202~209
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