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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
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- 1 - 9 (9page)
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Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins and phospholipids and modulate various cellular functions including macromolecular synthesis. Dysregulation of the polyamine pathway leads to pathological conditions including cancer, inflammation, stroke, renal failure and diabetes. Increase in polyamines and polyamine synthesis enzymes is often associated with tumor growth, and urinary and plasma contents of polyamines and their metabolites have been investigated as diagnostic markers for cancers. Of these, diacetylated derivatives of spermidine and spermine are elevated in the urine of cancer patients and present potential markers for early detection. Enhanced catabolism of cellular polyamines by polyamine oxidases (PAO), spermine oxidase (SMO) or acetylpolyamine oxidase (AcPAO), increases cellular oxidative stress and generates hydrogen peroxide and a reactive toxic metabolite, acrolein, which covalently incorporates into lysine residues of cellular proteins. Levels of protein-conjuagated acrolein (PC-Acro) and polyamine oxidizing enzymes were increased in the locus of brain infarction and in plasma in a mouse model of stroke and also in the plasma of stroke patients. When the combined measurements of PC-Acro, interleukin 6 (IL-6), and C-reactive protein (CRP) were evaluated, even silent brain infarction (SBI) was detected with high sensitivity and specificity. Considering that there are no reliable biochemical markers for early stage of stroke, PC-Acro and PAOs present promising markers. Thus the polyamine metabolites in plasma or urine provide useful tools in early diagnosis of cancer and stroke.
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참고문헌 (88)
참고문헌 신청
Agostinelli, E. / 2010 / Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach / Amino Acids 38:353~368
Auvinen, M. / 1992 / Ornithine decarboxylase activity is critical for cell transformation / Nature 360:355~358
Babbar, N. / 2007 / Inflammation and polyamine catabolism: the good, the bad and the ugly / Biochem. Soc. Trans 35:300~304
Bachrach, U. / 2005 / Naturally occurring polyamines: interaction with macromolecules / Curr. Protein Pept. Sci 6:559~566
Becerra-Solano, L. E. / 2009 / A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome / Am. J. Med. Genet. A 149:328~335
Auvinen, M. / 1992 / Ornithine decarboxylase activity is critical for cell transformation / Nature 360:355~358
Babbar, N. / 2007 / Inflammation and polyamine catabolism: the good, the bad and the ugly / Biochem. Soc. Trans 35:300~304
Bachrach, U. / 2005 / Naturally occurring polyamines: interaction with macromolecules / Curr. Protein Pept. Sci 6:559~566
Becerra-Solano, L. E. / 2009 / A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome / Am. J. Med. Genet. A 149:328~335
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