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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 207 - 213 (7page)
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The present study examined the effects of krill-derived phosphatidylserine (Krill-PS) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered vehicle (medium-chain triglyceride: MCT) or Krill-PS (50, 100 mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of Krill-PS in TMT-induced amnesic rats was investigated by assessing the Morris water maze test and by performing choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and cAMP responsive element binding protein (CREB) immunohistochemistry. The rats with TMT injection showed impaired learning and memory of the tasks and treatment with Krill-PS produced a significant improvement of the escape latency to find the platform in the Morris water maze at the $2^{nd}$ and $4^{th}$ day compared to that of the MCT group (p<0.05). In the retention test, the Krill-PS+MCT groups showed increased time spent around the platform compared to that of the MCT group. Consistent with the behavioral data, Krill-PS 50+MCT group significantly alleviated the loss of acetylcholinergic neurons in the hippocampus and medial septum compared to that of the MCT group. Treatment with Krill-PS significantly increased the CREB positive neurons in the hippocampal CA1 area as compared to that of the MCT group. These results suggest that Krill-PS may be useful for improving the cognitive function via regulation of cholinergic marker enzyme activity and neural activity.
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참고문헌 (52)
참고문헌 신청
Alessandri, B. / 1994 / The use of an unbaited tunnel maze in neurotoxicology: I. Trimethyltin-induced brain lesions / Neurotoxicology 15:349~357
Andersson, H. / 1995 / Timecourse of trimethyltin effects on the monoaminergic systems of the rat brain / Neurotoxicology 16:201~210
Balaban, C. D. / 1988 / Trimethyltin- induced neuronal damage in the rat brain: comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins / Neuroscience 26:337~361
Bourtchuladze, R. / 1994 / Defi cient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein / Cell 79:59~68
Cannon, R. L. / 1994 / Effects of trimethyltin (TMT) on choline acetyltransferase activity in the rat hippocampus. Infl uence of dose and time following exposure / Mol. Chem. Neuropathol 23:27~45
Andersson, H. / 1995 / Timecourse of trimethyltin effects on the monoaminergic systems of the rat brain / Neurotoxicology 16:201~210
Balaban, C. D. / 1988 / Trimethyltin- induced neuronal damage in the rat brain: comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins / Neuroscience 26:337~361
Bourtchuladze, R. / 1994 / Defi cient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein / Cell 79:59~68
Cannon, R. L. / 1994 / Effects of trimethyltin (TMT) on choline acetyltransferase activity in the rat hippocampus. Infl uence of dose and time following exposure / Mol. Chem. Neuropathol 23:27~45
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