지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 153 - 160 (8page)
이용수
초록· 키워드
오류제보하기
We screened the pharmacological effects of a 50% ethanol extract of Yacon tubers and leaves on spermatogenesis in rats. As a result, we found that Yacon tuber extracts increased sperm number and serum testosterone level in rats. It has been reported that the crude extract of Yacon tubers and leaves contain phenolic acids, such as, chlorogenic acid, ferulic acid and caffeic acid by HPLC/MS analysis. We were interested in the contributions made by phenolic acid, particularly chlorogenic acid of Yacon tuber extract to the spermatogenic activity. After administering Yacon tuber extract or chlorogenic acid to rats for 5 weeks, numbers of sperm in epididymis were increased by 34% and 20%, respectively. We also administered ferulic acid, which has been reported to be a metabolite of chlorogenic acid and a constituent of Yacon tuber extract to investigate its spermatogenic activity in rats. Yacon tuber extract and ferulic acid increased sperm numbers by 43% and 37%, respectively. And, Yacon tuber extract, and chlorogenic acid showed significantly inhibition effect of testoeterone degradation in rat liver homogenate. We considered that the spermatogenic effect of Yacon tuber extract might be related to phenolic compounds and their inhibitory effect of testosterone degradation. Yacon showed the possibility as ameliorable agents of infertility by sperm deficiency and late onset hypogonadism syndrome with low level of testosterone.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Abdel-Magied, E. M. / 2001 / The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats / J. Ethnopharmacol 75:1~4
Ahmad, M. K. / 2008 / Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men / Fertil. Steril 90:627~635
Archer, S. / 1993 / Measurement of nitric oxide in biological models / FASEB J 7:349~360
Aybar, M. J. / 2001 / Hypoglycemic effect of the water extract of Smallanthus sonchifolius (yacon) leaves in normal and diabetic rats / J. Ethnopharmacol 74:125~132
Barcellona, C. S. / 2012 / Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin / J. Ethnopharmacol 144:362~370
Ahmad, M. K. / 2008 / Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men / Fertil. Steril 90:627~635
Archer, S. / 1993 / Measurement of nitric oxide in biological models / FASEB J 7:349~360
Aybar, M. J. / 2001 / Hypoglycemic effect of the water extract of Smallanthus sonchifolius (yacon) leaves in normal and diabetic rats / J. Ethnopharmacol 74:125~132
Barcellona, C. S. / 2012 / Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin / J. Ethnopharmacol 144:362~370
이 논문의 저자 정보
최근 본 자료
댓글(0)
0