지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 477 - 486 (10page)
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초록· 키워드
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The purpose of the present study was to investigate whether polyphenol-rich fraction extracted from fruit wine of Rubus coreanum M (PCRC) can affect the contractility of the thoacic aortic strips isolated from spontaneously hypertensive rats (SHRs), and to clarify its mechanism of action. PCRC (200-800 ${\mu}g/mL$) concentration-depenedently blocked phenylephrine (10 ${\mu}M$)-induced contractile responses of the isolated aortic strips of SHRs. PCRC (400 ${\mu}g/mL$), added in to bath medium, also depressed the contractile active tension evoked by both phenylephrine (3 and 10 ${\mu}M$) and high potassium (25 and 56 mM). In the simultaneous presence of PCRC (400 ${\mu}g/mL$) and L-NAME (a selective inhibitor of NO synthase, 300 ${\mu}M$), the contractile responses evoked by phenylephrine and high $K^+$ were recovered to considerable level of the corresponding control contractility compared with those effects of PCRC-treatment alone. However, in the simultaneous presence of indomethacin (10 ${\mu}M$, a selective cyclooxygenase inhibitor) and PCRC (400 ${\mu}g/mL$), they were not affected. In the endothelium-denuded aortic strips by CHAPS-treatment, PCRC did not affect the contractile responses induced by phenylephrine or high potassium. Interestingly, PCRC (1.0, 3.0 and 10.0 mg/kg/30 min, i.v., respectively) dose-dependently suppressed norepiphrine-induced vasopressor responses in anesthetized SHRs. Collectively, we concluded that PCRC causes vasorelaxation in the thoracic aortic strips with intact endothelium of SHRs at least partly by the increased NO production through the activation of NO synthase of vascular endothelium, but not through the activation of cyclooxygenase. These results suggest that PCRC might be helpful to prevent or alleviate cardiovascular diseases, including hypertension.
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참고문헌 (61)
참고문헌 신청
Ablad, B. / 1975 / A survey of the pharmacological properties of metoprolol in animals and man / Acta. Pharmacol. Toxicol 36:7~23
Aldini, G / 2003 / Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection / Life Sci 73:2883~2898
Andriambeloson, E / 1998 / Lobstein Natural dietary polyphenolic compounds cause endotheliumdependent vasorelaxation in rat thoracic aorta / J. Nutr 128:2324~2333
Andriambeloson, E. / 1999 / Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta / J. Cardiovasc. Pharmacol 33:248~254
Benito, S / 2002 / A fl avonoid-rich diet increases nitric oxide production in rat aorta / Br. J. Pharmacol 135:910~916
Aldini, G / 2003 / Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection / Life Sci 73:2883~2898
Andriambeloson, E / 1998 / Lobstein Natural dietary polyphenolic compounds cause endotheliumdependent vasorelaxation in rat thoracic aorta / J. Nutr 128:2324~2333
Andriambeloson, E. / 1999 / Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta / J. Cardiovasc. Pharmacol 33:248~254
Benito, S / 2002 / A fl avonoid-rich diet increases nitric oxide production in rat aorta / Br. J. Pharmacol 135:910~916
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