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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 345 - 353 (9page)
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초록· 키워드
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Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.
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참고문헌 (90)
참고문헌 신청
Andrianov, V. / 2010 / Production of recombinant anthrax toxin receptor (ATR/CMG2) fused with human Fc in planta / Protein Expr. Purif 70:158~162
Bachmann, M. F. / 2010 / Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns / Nat. Rev. Immunol 10:787~796
Bendandi, M. / 2010 / Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin’s lymphoma / Ann. Oncol 21:2420~2427
Bhoo, S. H. / 2006 / Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana / Plant Biotechnol. J 9:807~816
Brodzik, R. / 2006 / Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells / Proc. Nati. Acad. Sci. U.S.A 103:8804~8809
Bachmann, M. F. / 2010 / Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns / Nat. Rev. Immunol 10:787~796
Bendandi, M. / 2010 / Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin’s lymphoma / Ann. Oncol 21:2420~2427
Bhoo, S. H. / 2006 / Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana / Plant Biotechnol. J 9:807~816
Brodzik, R. / 2006 / Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells / Proc. Nati. Acad. Sci. U.S.A 103:8804~8809
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