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논문 기본 정보

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학술저널
저자정보
Lee, Eun Byeol (College of Pharmacy, Woosuk University) Kim, Jun Hyeong (College of Pharmacy, Woosuk University) An, Chang Wan (College of Pharmacy, Woosuk University) Kim, Yeong Jee (College of Pharmacy, Woosuk University) Noh, Yun Jeong (College of Pharmacy, Woosuk University) Kim, Su Jin (College of Pharmacy, Woosuk University) Kim, Ju-Eun (College of Pharmacy, Woosuk University) Shrestha, Abinash Chandra (College of Pharmacy, Woosuk University) Ham, Ha-Neul (College of Pharmacy, Woosuk University) Leem, Jae-Yoon (College of Pharmacy, Woosuk University) Jo, Hyung-Kwon (Hanpoong Pharm. Co., LTD) Kim, Dae-Sung (Hanpoong Pharm. Co., LTD) Moon, Kwang Hyun (Sunchang Research Institute of Health and Longevity) Lee, Jeong Ho (Sunchang Research Institute of Health and Longevity) Jeong, Kyung Ok (Sunchang Research Institute of Health and Longevity) Kim, Dae Keun (College of Pharmacy, Woosuk University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제26권 제6호
발행연도
2018.1
수록면
568 - 575 (8page)

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In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.

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