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논문 기본 정보

자료유형
학술저널
저자정보
Yamabe, Noriko (Department of Food Science and Nutrition, Pusan National University) Kang, Ki Sung (College of Korean Medicine, Gachon University) Lee, Ah Young (Department of Food Science and Nutrition, Pusan National University) Lee, Dahae (College of Korean Medicine, Gachon University) Choi, Ji Myung (Department of Food Science and Nutrition, Pusan National University) Lee, Sullim (Department of Integrative Plant Science, Chung-Ang University) Park, Jun Yeon (Department of Integrative Plant Science, Chung-Ang University) Hwang, Gwi Seo (College of Korean Medicine, Gachon University) Kim, Hyun Young (Department of Food Science, Gyeongnam National University of Science and Technology) Cho, Eun-Ju (Department of Food Science and Nutrition, Pusan National University) Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제57권 제2호
발행연도
2014.1
수록면
187 - 190 (4page)

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Anti-cancer effects were compared amongst Taraxacum coreanum extract, its fractions, and 7 ingredients (${\beta}$-sitosterol, daucosterol, taraxasteryl acetate, chrysoeriol, diosmetin, luteolin, and luteoloside). Exposure to the ethyl acetate fraction (50 and $100{\mu}g/mL$) of T. coreanum extract and luteolin (10 and $50{\mu}M$) for 24 h induced the cleavage of poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-8, in a dose-dependent manner. These findings demonstrate that luteolin is the main active component of T. coreanum extract activating caspases-3 and -8 which contribute to apoptotic cell death.

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