지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 540 - 546 (7page)
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초록· 키워드
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The high mortality rates associated with cancer reflect the metastatic spread of tumor cells from the site of their origin. Metastasis, in fact, is the cause of 90% of cancer deaths. Therefore, considerable effort is being made to inhibit metastasis. In the present study, we screened ketotifen for anti-migratory and anti-invasive activities against MDA-MB-231 breast cancer and HT-1080 fibrosarcoma cancer cells. Cancer cell migration and invasion were measured using multi-well chambers. Additionally, western blots were used to examine the effects of ketotifen on the expressions of CDC42, Rho, Rac, and matrix metalloproteinase 9 (MMP-9). The results showed that ketotifen dose-dependently suppressed the migration and invasion of MDA-MB-231 and HT-1080 cells. Ketotifen also suppressed the expressions of CDC42, Rac, and Rho, which, significantly, are involved in MDA-MB-231 and HT-1080 cancer cell migration. Moreover, ketotifen suppressed the expression and activity of MMP-9, which is involved in degradation of the extracellular matrix leading to invasion. The overall data suggested that ketotifen suppresses the migration and invasion of MDA-MB-231 and HT-1080 cancer cells via inhibition of CDC42, Rac, Rho, and MMP-9 expression.
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참고문헌 (40)
참고문헌 신청
Aspenstrom, P / 2004 / Integration of signalling pathways regulated bysmall GTPases and calcium / Biochim. Biophys. Acta 1742:51~58
Bravo-Cordero, J. J / 2012 / Directedcell invasion and migration during metastasis / Curr. Opin. Cell Biol 24:277~283
Bray, K / 2013 / Cdc42 overexpression induces hyperbranchingin the developing mammary gland by enhancing cellmigration / Breast Cancer Res 15:R91
Brinckerhoff, C. E / 2002 / Matrix metalloproteinases:a tail of a frog that became a prince / Nat.Rev. Mol. Cell Biol 3:207~214
Cailleau, R / 1974 / Breasttumor cell lines from pleural effusions / J. Natl. Cancer Inst 53:661~674
Bravo-Cordero, J. J / 2012 / Directedcell invasion and migration during metastasis / Curr. Opin. Cell Biol 24:277~283
Bray, K / 2013 / Cdc42 overexpression induces hyperbranchingin the developing mammary gland by enhancing cellmigration / Breast Cancer Res 15:R91
Brinckerhoff, C. E / 2002 / Matrix metalloproteinases:a tail of a frog that became a prince / Nat.Rev. Mol. Cell Biol 3:207~214
Cailleau, R / 1974 / Breasttumor cell lines from pleural effusions / J. Natl. Cancer Inst 53:661~674
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