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논문 기본 정보

자료유형
학술저널
저자정보
Suh, Dong-Churl (College of Pharmacy, Chung-Ang University) Kim, Yeongseok (College of Pharmacy, Chung-Ang University) Kim, Hyeongmin (College of Pharmacy, Chung-Ang University) Ro, Jieun (College of Pharmacy, Chung-Ang University) Cho, Seong-Wan (Department of Pharmaceutics and Biotechnology, Medical Engineering College, Konyang University) Yun, Gyiae (Department of Food Science and Technology, Chung-Ang University) Choi, Sung-Up (Department of Food Science and Biotechnology, Dongnam Health College) Lee, Jaehwi (College of Pharmacy, Chung-Ang University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제22권 제1호
발행연도
2014.1
수록면
73 - 77 (5page)

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The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed using Franz diffusion cells along with rat dorsal skin, and the effect of drug concentration and the addition of pectin on skin deposition profiles of RP was observed. The skin distribution of RP increased in a concentration dependent manner and the formulations containing 0.5 and 1 mg of pectin demonstrated significantly increased RP distributions in the epidermis. Furthermore, it was found that skin distribution of RP could be further improved by combined use of pectin and ascorbyl palmitate (AP), due largely to their anti-oxidative effect. These results clearly demonstrate that the skin deposition properties of RP can be improved by stabilizing RP with pectin. Therefore, it is strongly suggested that pectin could be used in the pharmaceutical and cosmetic formulations as an efficient stabilizing agent and as skin penetration modulator.

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