지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 66 - 71 (6page)
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초록· 키워드
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Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-inflammatory activity against several animal models of inflammation, especially against an animal model of acute bronchitis. In the present investigation, the effects of BL on animal models of septic inflammation and chronic bronchitis are examined. Against lipopolysaccharide (LPS)-induced septic inflammation in mice, BL (200-400 mg/kg) reduced the induction of some important proinflammatory cytokines. At 1 h after LPS treatment, BL was found to considerably inhibit TNF-${\alpha}$ production when measured by cytokine array. At 3 h after LPS treatment, BL inhibited the induction of several proinflammatory cytokines, including IFN-${\gamma}$ and IL-$1{\beta}$, although dexamethasone, which was used as a reference, showed a higher inhibitory action on these biomarkers. Against chronic bronchitis induced by LPS/elastase instillation in rats for 4 weeks, BL (200-400 mg/kg/day) significantly inhibited cell recruitment in bronchoalveolar lavage fluid. Furthermore, BL considerably reduced lung injury, as revealed by histological observation. Taken together, these results indicate that BL may have a potential to treat systemic septic inflammation as well as chronic bronchitis.
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참고문헌 (16)
참고문헌 신청
Barnes, P. J. / 1999 / Novel approaches and targets for treatment of chronic obstructive pulmonary disease / Am. J. Respir. Crit. Care Med 160:72~79
Batt, D. G. / 1992 / 5-Lipoxygenase inhibitors and their anti-inflammatory activities / Prog. Med. Chem 29:1~63
Cheng, Z. J. / 2001 / Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages / Biochem. Pharmacol 61:939~946
Chi, Y. S. / 2001 / Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases / Biochem. Pharmacol 62:1185~1191
Ganesan, S. / 2010 / Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression / Respir. Res 11:113
Batt, D. G. / 1992 / 5-Lipoxygenase inhibitors and their anti-inflammatory activities / Prog. Med. Chem 29:1~63
Cheng, Z. J. / 2001 / Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages / Biochem. Pharmacol 61:939~946
Chi, Y. S. / 2001 / Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases / Biochem. Pharmacol 62:1185~1191
Ganesan, S. / 2010 / Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression / Respir. Res 11:113
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